Browsing by Author "Correia, Maria"
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- # 10. Identificação na saliva de biomarcadores de suscetibilidade à cárie dentáriaPublication . Lourenço, Carolina; Rosa, Nuno; Correia, Maria; Barros, Maria
- #146. miRNAs salivares como biomarcadores da Diabetes Mellitus tipo IIPublication . Martins, Alexandra; Santos, Luís Silva; Rosa, Nuno; Correia, MariaObjetivos: Estudar o potencial de miRNAs salivares como biomarcadores em DMT2, pela revisão sistemática da evidência disponível sobre alterações de expressão de miRNAs associadas a DMT2, e identificar os miRNAs que, por terem expressão alterada em DMT2 e terem já sido detetados na saliva, são candidatos promissores a utilização como biomarcadores salivares de DMT2. Materiais e métodos: Pesquisa sistemática nas bases de dados PubMed, Web of Science e Science Direct, para identificação de estudos em que os miRNAs tenham sido quantificados em pacientes com DMT2 e construção de uma base de dados com a anotação dos resultados desses artigos. Análise estatística dos resultados globais para verificar quais os miRNAs que podem configurar biomarcadores DMT2. Verificar dos miRNAs identificados se alguns foram já identificados em fluidos orais e/ou quais os que podem ser encontrados nestes fluidos. Resultados: Foram encontrados 776 artigos não duplicados que referem miRNAs como biomarcadores para DMT2, dos quais foram selecionados 115, sendo apenas 31 incluídos nos resultados. Da análise desses artigos, verificou‐se que 53 miRNAs foram encontrados como estando alterados em amostras de pacientes diabéticos vs. amostras de pacientes com tolerância normal à glicose, e 17 estão alterados quando se comparam pacientes com tolerância normal à glicose e tolerância alterada à glicose (pré‐diabéticos). Entre estes 2 grupos de comparações, há 12 miRNAs comuns em que 3 estão aumentados em DMT2, 2 estão diminuídos e 5 estão contrarregulados. Todos estes miRNAs encontram‐se na saliva, contudo o melhor candidato a biomarcador é o hsa‐miR‐375, porque está consistentemente alterado e tem uma alteração (fold change de 1,72). Conclusões: Estudos têm demonstrado que existem perfis específicos de microRNA em paciente com DMT2, em comparação com pacientes sem DMT2. Esta informação é relevante, pois os microRNA podem ser utilizados como biomarcadores para o diagnóstico e prognóstico, bem como potenciais alvos terapêuticos da DMT2. Por fim, existem alguns estudos, em que a amostra não é a saliva, que indicam o hsa‐miR‐375 como biomarcador da DMT2. Contudo, é necessário mais estudos de validação do hsa‐miR‐375 como biomarcador salivar na DMT2.
- Bacterial resistance in the context of oral healthPublication . Ribeiro, Isabel; Rosa, Nuno; Barros, Marlene; Correia, Maria
- Biocompatibility and effectiveness of a novel organic olive oil-based denture adhesive: a multicenter randomized and placebo-controlled clinical trialPublication . Azevedo, Luís; Correia, André; Almeida, Carlos F.; Molinero-Mourelle, Pedro; Correia, Maria; Hisghsmith, Jaime Del RíoTo assess the clinical efficacy of a novel organic olive oil-based denture adhesive and its effect on Candida Albicans growth in maxillary edentulous individuals wearing complete dentures. Individuals were selected from two Dental Schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (Test) was compared with a commercialized adhesive (Control) and Vaseline (Placebo) randomly assigned in a crossstudy design. The retention resistance was measured with a Gnathometer and a dynamometer, the patient related outcome evaluations with a 5-points questionnaire and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium in order to evaluate differences between the placebo and experimental product. Twenty-three participants were included. Dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = .03; control, p = .04), no significant differences between the two adhesives (p > .05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = .001); the control reported better results at taste (p = .03) in chewing (p = .001). The test adhesive showed better (p < .001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and placebo with a better inhibition capacity for the growth of Candida albicans, patients reported better abilities for speech, chewing, taste and retirement in the control adhesive.
- Biocompatibility and effectiveness of a novel, organic olive oil-based denture adhesive: a multicenter randomized and placebo-controlled clinical trialPublication . Azevedo, Luís; Correia, André; Almeida, Carlos F.; Molinero-Mourelle, Pedro; Correia, Maria; Highsmith, Jaime del RíoTo assess the clinical efficacy of a novel, organic olive oil-based denture adhesive and its effect on Candida albicans growth in maxillary edentulous individuals wearing complete dentures, individuals were selected from two dental schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (test) was compared with a commercialized adhesive (control) and Vaseline (placebo) randomly assigned in a cross-study design. The retention resistance was measured with a gnathometer and a dynamometer. The patients related outcome evaluations with a five-point questionnaire, and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium was used to evaluate differences between the placebo and experimental product. Twenty-three participants were included. The dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = 0.03; control, p = 0.04) and no significant differences between the two adhesives (p > 0.05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = 0.001), and the control reported better results in taste (p = 0.03) and in chewing (p = 0.001). The test adhesive showed better (p < 0.001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and the placebo with a better inhibition capacity for the growth of Candida albicans. Patients reported better abilities for speech, chewing, taste, and retirement in the control adhesive.
- Current state of professionalism curriculum in oral health educationPublication . Nasseripour, Melanie; Agouropoulos, Andreas; Harten, Maria Theresa Van; Correia, Maria; Sabri, Nibal; Rollman, AnnemiekAim: The aim of this study was to systematically review the relevant literature on teaching professionalism in dental curricula and report the relevant data from a survey of members of the Association for Dental Education in Europe (ADEE) on the topic. Materials and Methods: We conducted a systematic review of the literature and a cross-sectional study using an online questionnaire regarding teaching and assessment of professionalism in dental schools, members of the ADEE. The literature review identified 33 articles related to professionalism in dental curricula. The survey sent to the membership of the Association for Dental Education in Europe yielded responses from 27 European dental schools and four schools outside Europe. Results: Various study designs were identified in the review, and the main themes discussed included teaching/pedagogy, ethics/humanities, core domains and assessment of professionalism. Twenty schools reported having specific courses dedicated to professionalism, while the format varied, including entire modules, separate learning outcomes or unit structures. Ethics, communication, law/legal framework/deontology, teamworking and management/leadership were among the common topics taught under the banner of professionalism. Many schools reported increases or no changes in hours, staffing, themes/topics covered and weight in the curriculum for professionalism over the last decade. Conclusion: The paper provides valuable insights into the current state of professionalism education in dental curricula and offers directions for enhancing its effectiveness and relevance in preparing future dental professionals. Collaborative efforts among dental educators and institutions can contribute to the continuous improvement of professionalism education and practice in dentistry.
- Embedding environmental sustainability within the modern dental curriculum – exploring current practice and developing a shared understandingPublication . Duane, Brett; Dixon, Jonathan; Ambibola, Giwa; Aldana, Clara; Couglan, James; Henao, Daniel; Timus, Daniela; Veiga, Nélio; Martin, Nicolas; Darragh, Jáuregui‐Hogan; Ramasubbu, Darshini; Perez, Francesc; Schwendicke, Falk; Correia, Maria; Quinteros, Maria; Harten, Maria van; Paganelli, Corrado; Vos, Peter; Lopez, Rosa Moreno; Field, JamesIntroduction: Evidence concerning the interactions between human health and planetary health has grown extensively in recent years. In turn, the perceived importance of environmental sustainability within higher education is growing at a rapid rate. This paper provides a summary of key elements as they apply to dentistry, and provides an introduction to the reader of an early consensus of how sustainability could be included as part of the dental curriculum. Methods: The consensus opinion within this paper largely centres around discussion at the ADEE sustainability workshop at the annual conference in Berlin (August 2019). In order to help inform discussions at the workshop, a brief scoping questionnaire was circulated to potential participants regarding their understanding and current teaching practices in sustainability. An infographic was designed to help delegates remember the important elements of sustainable dentistry. Delegates discussed the concept of sustainability alongside the infographic, and how they could link these with the Graduating European Dentist (GED) curriculum. Results: The discussions within the workshop largely centred around 4 main themes: Disease prevention and health promotion, Patient education and empowerment, Lean service delivery and Preferential use of strategies with lower environmental impact. Discussion: It is apparent that there is a widespread need for teaching materials relating to environmental sustainability; this includes specific learning outcomes relating to the 4 educational domains of the Graduating European Dentist curriculum, and methods for teaching and assessing these outcomes. Conclusion: This paper reports consensus on the first phase of a pan‐European working group on Sustainability in dental education.
- Estudo comparativo de comportamentos e autoperceção em saúde oral de populações adultas com e sem deficiência intelectualPublication . Martins, Inês; Veiga, Nélio; Correia, Maria; Coelho, Inês; Couto, PatríciaObjetivos: Comparar os comportamentos de saúde oral e a autoperceção da necessidade de tratamento em populações adultas com e sem deficiência intelectual. Métodos: Foi realizado um estudo de prevalência numa amostra de conveniência de 480 indivíduos com idades compreendidas entre os 18-64 anos (240 indivíduos com deficiência intelectual leve filiados na HUMANITAS e 240 sem deficiência, utentes da Clínica Universitária da Universidade Católica Portuguesa), através da aplicação de um questionário sociodemográfico e de saúde oral onde se pretende avaliar: número de dentes naturais; frequência e técnicas de higienização; periodicidade e motivo das consultas médico-dentárias; autoperceção da condição oral e necessidade de tratamentos. A análise estatística foi realizada no software SPSS versão 22.0, com recurso aos testes estatísticos Qui-Quadrado e Mann-Whitney. Resultados: Relativamente à condição oral da população com deficiência verificou-se que 32,9% dos indivíduos tinha menos de 20 dentes, valor este superior ao da população sem deficiência (10%). Também a percentagem de higienização oral diária foi inferior na população com deficiência (79,6% vs 94,2%), assim como o uso de fio dentário (7,1% vs 47,1%) ou elixir (24,1% vs 49,2%). Verificámos ainda nos indivíduos com deficiência uma menor percentagem de consultas médico-dentárias nos últimos 6 meses (28,4% vs 59,2%), especialmente por motivo de rotina (18,8% vs 46,3%), uma maior autoperceção da necessidade de tratamento (75,2% vs 56,7%), e uma autoperceção menos favorável da condição oral, já que menos de metade (37,4% vs 56,2%) da amostra descreveu a sua condição oral como boa ou superior. Conclusões: Apesar dos fracos resultados gerais obtidos em ambas as populações, os comportamentos de saúde oral da população com deficiência intelectual são inferiores aos da população sem deficiência. Assim, a formação dos profissionais de saúde, dos cuidadores e a implementação de programas públicos de saúde oral são essenciais para melhorar a saúde oral destes indivíduos.
- FMD-Caries Risk Assessment Index - a new caries risk assessment index including salivary and microbiological factorsPublication . Lopes, Pedro; Fonseca, André; Ribeiro, Vanessa; Mendes, Ana; Gomes, Ana; Pinto, Marla; Rio, Rute; Correia, Maria
- Microbial DNA extraction methods for microbial screening - saliva vs biofilm comparisonPublication . Gomes, Ana T. P. C.; Pinto, Marla; Abrantes, Patrícia; Almeida, Rita; Mendes, Karina; Duarte, Ana S.; Silva, Raquel M.; Rosa, Nuno; Correia, Maria; Barros, Marlene
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