FMD - Dissertações de Mestrado / Master Dissertations
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- Association between oral condition in a population of portuguese children and quality of lifePublication . Ferreira, Nícia Filipa Martins; Moura, Anna Carolina Volpi Mello de; Veiga, Nélio Jorge; Alves, Renata ToledoIntroduction: Studies show a high prevalence of oral problems in children, affecting the quality of life related to oral health. There is a lack of comprehensive epidemiological studies on the oral conditions of Portuguese children. Objectives: To evaluate the prevalence of caries, consequences of non-treatment, malocclusion, traumatic dental injuries and MIH in a population of Portuguese children, verifying their association and sociodemographic characteristics with quality of life related to oral health. Methods: After approval by the Health Ethics Committee (CES-UCP no. 30/2019), the study included children aged 3 to 12 years and their guardians. Sociodemographic information and quality of life assessed by the ECOHIS-Pt or P-CPQ-Pt instruments via interview. Clinical data were obtained by oral examination. Statistical analysis compared groups using Student's t test, adopting a significance level of 5% (P < 0.05). Results: 131 children participated in the study, 76 females, 73 with mixed dentition, most living in urban areas, with parents who had between 10 and 12 years of education and a family income of two or more local minimum wages. The prevalence of caries was 48.1% and 9.2% with consequences of non-treatment. More than 80% of children had malocclusion, 16.8% had a history of traumatic dental injuries, and 15.3% had MIH. The average scores showed good quality of life related to oral health. There was an association between quality of life and place of residence, parents' marital status, mother's professional status, monthly family income, tooth decay and traumatic dental injuries, with a greater impact among children under 6 years of age. Conclusion: Portuguese children have a high prevalence of oral diseases, and these have a negative impact on the quality of life of preschool children.
- Exploring the effects of isolated flavonoids or formulations as antimicrobial/antibiofilm agents for endodontic treatment : a scoping reviewPublication . Saint-Etienne, Élise Lucie; Duque, Cristiane; Alves, Renata ToledoThis scoping review aimed to map and summarize the evidence on the antimicrobial and antibiofilm efficacy of flavonoid-based solutions or formulations for endodontic applications. The review was conducted in accordance with the PRISMA-ScR guidelines. A comprehensive search was performed across databases for articles published up to April 2025. Eligible studies included those evaluating the antimicrobial effects of flavonoids on microorganisms associated with endodontic infections. Relevant data were extracted, and a descriptive synthesis of the findings was carried out. The results showed that fifteen studies met the inclusion criteria, demonstrating significant antimicrobial and antibiofilm activity of various flavonoids. Epigallocatechin- 3-gallate was the most extensively studied compound, showing dose-dependent activity against E. faecalis, F. nucleatum, A. israelii, S. mutans, and C. albicans, with enhanced efficacy when combined with agents such as fosfomycin or KR-12-a5. Quercetin also displayed concentration-dependent antibiofilm effects and gene modulation in E. faecalis. Proanthocyanidin showed superior efficacy compared to conventional irrigants, especially at higher concentrations. Rutin, although limited in standalone efficacy, showed promising results when used as a photosensitizer. Other flavonoids such as apigenin, theaflavin, isoquercitrin, ampelopsin, chalcone, and chrysin also demonstrated varying degrees of antimicrobial activity, often similar to or surpassing conventional agents like chlorhexidine and calcium hydroxide in specific models. In conclusion, flavonoids exhibit significant potential as alternative or adjunctive agents for endodontic disinfection, especially in biofilm-related infections. Their efficacy is influenced by compound type, concentration, formulation, and synergistic combinations. Further research, especially clinical trials, is warranted to validate their therapeutic applicability and optimize delivery systems for clinical use in endodontics.