FMD - Dissertações de Mestrado / Master Dissertations
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- Vertical bone augmentation with occlusive devices in preclinical in vivo studies : a systematic review and quality assessment using arrive guidelines and SYRCLE’s risk of bias toolPublication . Nagano, Cibele Pidorodeski; Fernandes, Gustavo Vicentis de Oliveira; Anagnostou, FaniSeveral bone reconstructive techniques associated or not with the existing biomaterials were postulated attempting to re-establish vertical bone augmentation, including occlusive devices. To date, the quality of the aforementioned space-providing devices in preclinical studies has not been evaluated. Hence, the present study aimed to systematically review the literature data regarding the use of occlusive devices in vertical bone augmentation calvaria model of preclinical studies, and to determine the quality of the investigations according to ARRIVE guidelines. The focus question was: “What is the quality of reporting of preclinical research for the study of occlusive devices in vertical bone augmentation, in particular regarding the height, the shape and the constituent material, compared with empty defects, where no bone grafting materials was used?” A literature search was conducted at PubMed and Embase, between January 1980 and May 2020, using specific search terms. Quality assessment was performed according ARRIVE guidelines for reporting of in vivo experiments in animal research, and risk of bias was performed using the SYRCLE tool. Following screening, 21 studies were eligible for the review. A total of 753 occlusive devices was provided among the included studies. Cylindrical shape was the most common used (61.90%), followed by hemispherical caps (28.56%). Eighteen studies provided high quality of assessment, whereas three investigations resulted in moderate quality. The present study provide insight of the osteoconductive ability of occlusive devices in conjunction with different biomaterials, in vertical bone augmentation preclinical experimentations. The results highlight the lack of homogeneity in reporting data on calvarial model studies, in which space-providing devices are advocated to promote extracortical bone formation. Furthermore, in order to improve quality, biofuncionality, safety and reproducibility, animal studies should be conducted by ARRIVE guidelines.