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Abstract(s)
Introdução: As crianças submetidas a tratamento antineoplásico manifestam
diversos efeitos colaterais devido á intensidade e continuidade dos tratamentos.
A mucosite oral é uma das lesões inflamatórias mais prevalentes e dolorosas
encontradas nesta população, divide-se em estágios que têm por base a
evolução clínica dos pacientes. Há diversas opções terapêuticas, como o reforço
na higienização oral, a crioterapia, a terapia com laser de baixa intensidade e
medicinas alternativas, ainda que careçam de suporte científico. O objetivo desta
revisão sistemática foi definir o grau de evidência destas medidas no controlo da
MO.
Materiais e métodos: A presente revisão sistemática teve por base as
guidelines PRISMA, tendo-se efetuado uma pesquisa nas bases de dados
PubMed/MEDLINE®, Embase e literatura cinzenta, nomeadamente NICE e a
TRIAL. De acordo com a questão de investigação e critérios de seleção, foram
selecionados os artigos realizados nos últimos 20 anos, em população menor de
18 anos, que estiveram ou estavam expostos a tratamento antineoplásico. A
pesquisa e triagem dos artigos foi realizada por duas revisoras independentes e
a qualidade dos estudos foi avaliada através da Newscastle-Ottawa scale.
Resultados: Após a combinação dos termos de pesquisa obteve-se um total de
11693 artigos, após aplicação dos respetivos filtros obteve-se um total de 281.
Foi realizada uma primeira leitura dos títulos e abstracts resultando em 23
artigos. Estes foram analisados por leitura integral, eliminando-se 17 artigos. Os
restantes 6 artigos integraram a presente revisão sistemática.
Conclusão: Existem diversas terapias disponíveis na prevenção e tratamento
da MO, no entanto, não há evidências conclusivas da sua eficácia para
estabelecer protocolos clínicos precisos. Conclui-se que, em específico, o laser
de baixa intensidade, a palifermina e a andibora demonstraram um efeito
preventivo no desenvolvimento, diminuição e, por vezes, eliminação da
sintomatologia.
Introduction: Children undergoing antineoplastic treatment manifest several side effects due to the intensity and continuity of treatments. Oral mucositis is one of the most prevalent and painful inflammatory lesions found in this population, divided into stages that are based on the clinical evolution of patients. There are several therapeutic options, such as reinforcement in oral hygiene, cryotherapy, low-intensity laser therapy and alternative medicines, even if they lack scientific support. The aim of this systematic review was to bring evidence in the management of OM. Materials and methods: This systematic review was based on the PRISMA guidelines, and a search was carried out in the PubMed/MEDLINE®, Embase and grey literature databases, namely NICE and TRIAL. According to the question of research and selection criteria, articles performed in the last 20 years, in a population under 18 years of age, who were or were exposed to antineoplastic treatment, were selected. The research and screening of the articles was carried out by two independent reviewers and the quality of the studies was evaluated through the Newscastle-Ottawa scale. Results: After combining the search terms, a total of 11693 articles were obtained, after applying the respective filters a total of 281 were obtained. A first reading of the titles and abstracts was performed resulting in 23 articles. These were analyzed by full reading, eliminating 17 articles. The remaining 6 articles were part of this systematic review. Conclusion: There are several therapies available in the prevention and treatment of OM, however, there is no conclusive evidence of its efficacy to establish accurate clinical protocols. It is concluded that, in particular, low intensity laser, palifermine and andibora demonstrated a preventive effect on the development, decrease and sometimes elimination of symptomatology.
Introduction: Children undergoing antineoplastic treatment manifest several side effects due to the intensity and continuity of treatments. Oral mucositis is one of the most prevalent and painful inflammatory lesions found in this population, divided into stages that are based on the clinical evolution of patients. There are several therapeutic options, such as reinforcement in oral hygiene, cryotherapy, low-intensity laser therapy and alternative medicines, even if they lack scientific support. The aim of this systematic review was to bring evidence in the management of OM. Materials and methods: This systematic review was based on the PRISMA guidelines, and a search was carried out in the PubMed/MEDLINE®, Embase and grey literature databases, namely NICE and TRIAL. According to the question of research and selection criteria, articles performed in the last 20 years, in a population under 18 years of age, who were or were exposed to antineoplastic treatment, were selected. The research and screening of the articles was carried out by two independent reviewers and the quality of the studies was evaluated through the Newscastle-Ottawa scale. Results: After combining the search terms, a total of 11693 articles were obtained, after applying the respective filters a total of 281 were obtained. A first reading of the titles and abstracts was performed resulting in 23 articles. These were analyzed by full reading, eliminating 17 articles. The remaining 6 articles were part of this systematic review. Conclusion: There are several therapies available in the prevention and treatment of OM, however, there is no conclusive evidence of its efficacy to establish accurate clinical protocols. It is concluded that, in particular, low intensity laser, palifermine and andibora demonstrated a preventive effect on the development, decrease and sometimes elimination of symptomatology.
Description
Keywords
Mucosite oral Pediátrico Quimioterapia Radioterapia Cancro Oral mucositis Paediatric Chemotherapy Radiotherapy Cancer