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Abstract(s)
Introdução: A reparação óssea envolve processos biológicos complexos mediados por moléculas sinalizadoras. As terapias utilizando irradiação a laser e com gás ozono emergem como alternativas promissoras no processo de regeneração óssea. Com efeito, o propósito desta revisão sistemática é avaliar os efeitos bioestimulatórios durante a reparação óssea empregando esses dois modelos de terapias alternativas, e analisando qual a concentração de ozono e potência dos lasers necessários para obter uma melhor resposta biomoduladora. Metodologia: A pesquisa foi efetuada através das bases de dados PubMed/Medline®, Web of Science®, Embase e Scopus® onde foram utilizados termos MeSH e termos de texto livre com os operadores booleanos AND e OR. Dois investigadores independentes com o auxílio da plataforma RAYYAN, fizeram a seleção dos artigos segundo o fluxograma das diretrizes PRISMA, e a concordância foi avaliada pelo coeficiente kappa de Cohen. Sucessivamente, os artigos foram analisados e escolhidos segundo os critérios de elegibilidade estabelecidos. Resultados: A investigação inicial identificou 60 artigos. Após a seleção através dos critérios de inclusão e exclusão, 5 artigos foram considerados adequados e depois da leitura do texto completo, foram incluídos no estudo. As terapias de irradiação a laser e ozono comparativamente com os grupos de controlo apresentaram resultados significativamente maiores em termos de regeneração óssea a longo prazo, sobretudo quando utilizadas nas fases inicias da cicatrização. Conclusão: Os resultados obtidos nesta revisão indicam que as terapias de ozono e laser demonstraram ser uma alternativa eficaz para acelerar a cicatrização e promover a regeneração óssea, mas a literatura carece de estudos clínicos. Contudo, a terapia com gás ozono revelou ser mais eficaz em termos de uma redução na reabsorção óssea e a terapia com laser mais eficaz na reparação óssea. Mesmo assim, mais estudos comparativos são necessários para determinar os parâmetros ideais de aplicação.
Introduction: Bone repair involves complex biological processes mediated by signaling molecules. Therapies using laser irradiation and ozone gas emerge as promising alternatives in the bone regeneration process. Indeed, the purpose of this systematic review is to evaluate the biostimulatory effects during bone repair using these two alternative therapy models, and analyzing the ozone concentration and laser power necessary to obtain a better biomodulatory response. Methodology: The research was carried out using the databases PubMed/Medline®, Web of Science®, Embase and Scopus® where MeSH terms and free text terms were used with the Boolean operators AND and OR. Two independent researchers, with the help of the RAYYAN platform, selected the articles according to the PRISMA guidelines flowchart, and agreement was assessed using Cohen's kappa coefficient. Successively, the articles were analyzed and chosen according to the established eligibility criteria. Results: The initial investigation identified 60 articles. After selection using the inclusion and exclusion criteria, 5 articles were considered suitable and after reading the full text, they were included in the study. Laser irradiation and ozone therapies compared to control groups showed significantly greater results in terms of long-term bone regeneration, especially when used in the early stages of healing. Conclusion: The results obtained in this review indicate that ozone and laser therapies have proven to be an effective alternative for accelerating healing and promoting bone regeneration, but the literature lacks clinical studies. However, ozone gas therapy proved to be more effective in terms of reducing bone resorption and laser therapy more effective in bone repair. Even so, more comparative studies are needed to determine the ideal application parameters.
Introduction: Bone repair involves complex biological processes mediated by signaling molecules. Therapies using laser irradiation and ozone gas emerge as promising alternatives in the bone regeneration process. Indeed, the purpose of this systematic review is to evaluate the biostimulatory effects during bone repair using these two alternative therapy models, and analyzing the ozone concentration and laser power necessary to obtain a better biomodulatory response. Methodology: The research was carried out using the databases PubMed/Medline®, Web of Science®, Embase and Scopus® where MeSH terms and free text terms were used with the Boolean operators AND and OR. Two independent researchers, with the help of the RAYYAN platform, selected the articles according to the PRISMA guidelines flowchart, and agreement was assessed using Cohen's kappa coefficient. Successively, the articles were analyzed and chosen according to the established eligibility criteria. Results: The initial investigation identified 60 articles. After selection using the inclusion and exclusion criteria, 5 articles were considered suitable and after reading the full text, they were included in the study. Laser irradiation and ozone therapies compared to control groups showed significantly greater results in terms of long-term bone regeneration, especially when used in the early stages of healing. Conclusion: The results obtained in this review indicate that ozone and laser therapies have proven to be an effective alternative for accelerating healing and promoting bone regeneration, but the literature lacks clinical studies. However, ozone gas therapy proved to be more effective in terms of reducing bone resorption and laser therapy more effective in bone repair. Even so, more comparative studies are needed to determine the ideal application parameters.
Description
Keywords
Bioestimulação Reparação óssea Regeneração óssea LLLT Fotobiomodulação Ozono Terapia com ozono Biostimulation Bone repair Bone regeneration Photobiomodulation Ozone Ozone Therapy