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Abstract(s)
A saúde e microbioma oral de indivíduos com doença inflamatória intestinal (DII) são
menos diversificados e podem encontrar-se em desequilíbrio comparativamente a
indivíduos saudáveis. Este estudo visa caracterizar a saúde oral de pacientes com DII,
permitindo o estabelecimento de um protocolo personalizado de cuidados de saúde oral.
Devido à influência do microbioma nesta patologia, este trabalho visa também caracterizar
e correlacionar o microbioma oral de pacientes com DII saúde oral e sistémica. Por fim, e
tratando-se de um processo inflamatório, a caracterização do perfil de biomarcadores
inflamatórios em amostras de saliva dos pacientes com DII foi realizada e correlacionada
com a saúde oral e sistémica.
Este estudo observacional transversal assentou em 3 estratégias de recolha de
dados: as características sociodemográficas, comportamentos de saúde oral e hábitos
diários bem como os aspetos de saúde sistémica foram avaliados através um questionário;
um exame intraoral com vista à condição dentária geral e periodontal; e a recolha de saliva
e biofilme de pacientes diagnosticados com DII que frequentam a consulta de
Gastroenterologia do Centro Hospitalar Tondela-Viseu. Foram avaliados 129 pacientes
com DII, dos quais 65,9% com Doença de Crohn e 34,1% com Colite Ulcerativa. 83,7% dos
participantes padecem de doença periodontal e 35,7% e 82,2 % dos participantes no estudo
tinham pelo menos uma peça dentária cariada e uma ausente, respetivamente.
Foi possível verificar que a cavidade oral de pacientes com DII possui abundâncias
aumentadas dos filos Firmicutes e Bacteroidetes, filos estes que incluem as bactérias
patogénicas fortemente associadas à DII. Foi ainda possível concluir que o perfil
inflamatório de pacientes com DII é distinto de pacientes sem DII com e sem doença
periodontal.
Este estudo permitiu gerar novos conhecimentos sobre a DII, abrindo novos
caminhos para futuros trabalhos com vista a adequar protocolos terapêuticos a cada
paciente, contribuindo para uma medicina de precisão e personalizada.
The oral health and microbiome of individuals with Inflammatory Bowel Disease (IBD) are less diverse and may be out of balance compared to healthy individuals. This study aims to characterize the oral health of patients with IBD, allowing the establishment of a personalized oral health care protocol. Due to the influence of the microbiome in IBD, this work also aims to characterize and correlate the oral microbiome of IBD patients with oral and systemic health. Finally, as an inflammatory process, the salivary inflammatory profile of IBD patients was also characterized and correlated with oral and systemic health. This cross-sectional observational study was based on 3 data collection strategies: sociodemographic characteristics, oral health behaviors and daily habits, as well systemic health aspects were assessed trough a questionnaire; an intraoral examination for dental and periodontal condition assessment; and the collection of saliva and biofilm samples from IBD patients who attend the Gastroenterology service at Centro Hospitalar Tondela-Viseu. 129 patients were evaluated, in which 65.9% with Crohn's Disease and 34.1% with Ulcerative Colitis. 83.7% of participants suffer from periodontal disease and 35.7% and 82.2% of the participants had at least one decayed and missing tooth, respectively. It was possible to verify that the oral cavity of IBD patients has increased abundances of Firmicutes and Bacteroidetes phyla, which include pathogenic bacteria strongly associated with IBD. It was also possible to verify that the salivary inflammatory profile of patients with IBD is different from patients without IBD with and without periodontal disease. This study had generated new insights on IBD, opening new perspectives for future works with the aim to develop adequate therapeutic protocols for each patient, towards a precision and personalized medicine.
The oral health and microbiome of individuals with Inflammatory Bowel Disease (IBD) are less diverse and may be out of balance compared to healthy individuals. This study aims to characterize the oral health of patients with IBD, allowing the establishment of a personalized oral health care protocol. Due to the influence of the microbiome in IBD, this work also aims to characterize and correlate the oral microbiome of IBD patients with oral and systemic health. Finally, as an inflammatory process, the salivary inflammatory profile of IBD patients was also characterized and correlated with oral and systemic health. This cross-sectional observational study was based on 3 data collection strategies: sociodemographic characteristics, oral health behaviors and daily habits, as well systemic health aspects were assessed trough a questionnaire; an intraoral examination for dental and periodontal condition assessment; and the collection of saliva and biofilm samples from IBD patients who attend the Gastroenterology service at Centro Hospitalar Tondela-Viseu. 129 patients were evaluated, in which 65.9% with Crohn's Disease and 34.1% with Ulcerative Colitis. 83.7% of participants suffer from periodontal disease and 35.7% and 82.2% of the participants had at least one decayed and missing tooth, respectively. It was possible to verify that the oral cavity of IBD patients has increased abundances of Firmicutes and Bacteroidetes phyla, which include pathogenic bacteria strongly associated with IBD. It was also possible to verify that the salivary inflammatory profile of patients with IBD is different from patients without IBD with and without periodontal disease. This study had generated new insights on IBD, opening new perspectives for future works with the aim to develop adequate therapeutic protocols for each patient, towards a precision and personalized medicine.
Description
Keywords
Doença inflamatória intestinal Disbiose Saliva Microbioma oral Perfil inflamatório Inflammatory bowel disease Dysbiosis Oral microbiome Inflammatory profile