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Impacto dos distúrbios do sono relacionados com o ritmo circadiano na relação do ciclo cortisol/melatonina e no processo metabólico celular : revisão sistemática
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Abstract(s)
Esta revisão sistemática incidiu sobre o impacto dos distúrbios do sono relacionados com o ritmo circadiano sobre os biomarcadores de cortisol e melatonina e ainda no metabolismo celular, especificamente em relação ao nível dos telómeros. O objetivo principal foi avaliar o impacto desses distúrbios nos biomarcadores fisiológicos de cortisol e melatonina e na atividade celular, em particular nos telómeros. Os critérios de elegibilidade foram selecionados com base nos fatores estruturantes da abordagem PICOS (P= População; I= Intervenção; C= Comparação; O= Desfecho; S= Desenho do estudo). A população (P) incluiu participantes com distúrbios do sono do ritmo circadiano. A intervenção (I) focou nos biomarcadores de cortisol, melatonina e telômeros. O grupo de comparação (C) incluiu indivíduos com padrões de sono regulares e alinhados com o ritmo circadiano natural. Os desfechos (O) incluíram a avaliação do comprimento dos telômeros, qualidade do sono, e níveis de cortisol e melatonina no sangue. Os desenhos dos estudos (S) incluíram ensaios de controle randomizados, estudos de coorte, caso-controle, transversais e de prevalência e incidência. As bases de dados utilizadas para a pesquisa foram Scielo, PubMed e Cochrane Data Base of Systematic Reviews, com pesquisa adicional tipo "bola de neve" para identificar estudos adicionais. As evidências dos estudos selecionados indicam uma associação entre as desregulações circadianas e variações nestes biomarcadores, com possíveis implicações no comprimento dos telômeros, sugerindo um papel nos processos de envelhecimento celular precoce e nos desequilíbrios metabólicos e hormonais. O envelhecimento celular e os desequilíbrios hormonais afetam a saúde oral, influenciando processos como a cicatrização de feridas, a resposta imune e o desenvolvimento de doença periodontal e cárie dentária. A regulação adequada do ritmo circadiano pode desempenhar um papel crucial na otimização dos cuidados dentários e no manejo de condições orais crônicas. No entanto, devese ter cautela na interpretação destes resultados devido às limitações metodológicas dos estudos incluídos e ao processo de revisão em si. A variabilidade nos desenhos dos estudos, bem como a heterogeneidade das amostras e métodos de medição, ressalta a necessidade de futuras e mais rigorosas investigações para esclarecer estas associações. Estes resultados reforçam a importância de sincronizar os ritmos biológicos internos com os ciclos naturais ambientais a fim de manter a saúde geral, na qual se inclui a saúde oral.
This systematic review focused on the impact of sleep disorders related to the circadian rhythm on cortisol and melatonin biomarkers and cellular metabolism, specifically regarding telomere length. The main objective was to evaluate the impact of these disorders on physiological biomarkers of cortisol and melatonin and on cellular activity, particularly concerning telomeres. Eligibility criteria were selected based on the structural factors of the PICOS approach (P= Population; I= Intervention; C= Comparison; O= Outcome; S= Study design). The population (P) included participants with circadian rhythm sleep disorders. The intervention (I) focused on cortisol, melatonin, and telomere biomarkers. The comparison group (C) included individuals with regular sleep patterns aligned with the natural circadian rhythm. The outcomes (O) included the evaluation of telomere length, sleep quality, and levels of cortisol and melatonin in the blood. The study designs (S) included randomized controlled trials, cohort studies, case-control studies, cross-sectional studies, and prevalence and incidence studies. The databases used for the research were Scielo, PubMed, and Cochrane Data Base of Systematic Reviews, with additional "snowball" searches to identify further studies. The evidence from the selected studies indicates an association between circadian dysregulation and variations in these biomarkers, with potential implications for telomere length, suggesting a role in early cellular aging processes and metabolic and hormonal imbalances. Cellular aging and hormonal imbalances affect oral health, influencing processes such as wound healing, immune response, and the development of periodontal disease and dental caries. Proper regulation of the circadian rhythm can play a crucial role in optimizing dental care and managing chronic oral conditions. However, caution is needed in interpreting these results due to the methodological limitations of the included studies and the review process itself. The variability in study designs, as well as the heterogeneity of samples and measurement methods, highlights the need for future and more rigorous investigations to clarify these associations. These results reinforce the importance of synchronizing internal biological rhythms with natural environmental cycles to maintain overall health, including oral health.
This systematic review focused on the impact of sleep disorders related to the circadian rhythm on cortisol and melatonin biomarkers and cellular metabolism, specifically regarding telomere length. The main objective was to evaluate the impact of these disorders on physiological biomarkers of cortisol and melatonin and on cellular activity, particularly concerning telomeres. Eligibility criteria were selected based on the structural factors of the PICOS approach (P= Population; I= Intervention; C= Comparison; O= Outcome; S= Study design). The population (P) included participants with circadian rhythm sleep disorders. The intervention (I) focused on cortisol, melatonin, and telomere biomarkers. The comparison group (C) included individuals with regular sleep patterns aligned with the natural circadian rhythm. The outcomes (O) included the evaluation of telomere length, sleep quality, and levels of cortisol and melatonin in the blood. The study designs (S) included randomized controlled trials, cohort studies, case-control studies, cross-sectional studies, and prevalence and incidence studies. The databases used for the research were Scielo, PubMed, and Cochrane Data Base of Systematic Reviews, with additional "snowball" searches to identify further studies. The evidence from the selected studies indicates an association between circadian dysregulation and variations in these biomarkers, with potential implications for telomere length, suggesting a role in early cellular aging processes and metabolic and hormonal imbalances. Cellular aging and hormonal imbalances affect oral health, influencing processes such as wound healing, immune response, and the development of periodontal disease and dental caries. Proper regulation of the circadian rhythm can play a crucial role in optimizing dental care and managing chronic oral conditions. However, caution is needed in interpreting these results due to the methodological limitations of the included studies and the review process itself. The variability in study designs, as well as the heterogeneity of samples and measurement methods, highlights the need for future and more rigorous investigations to clarify these associations. These results reinforce the importance of synchronizing internal biological rhythms with natural environmental cycles to maintain overall health, including oral health.
Description
Keywords
Distúrbios do sono Ritmo circadiano Biomarcadores Cortisol Melatonina Telómeros Envelhecimento celular Saúde oral Cicatrização de feridas Doença periodontal Cárie dentária Sleep disorders Circadian rhythm Biomarkers Melatonin Telomeres Cellular aging Oral health Wound healing Periodontal disease Dental caries