Comparison between tooth-derived matrix and DBBM granules on an enhanced bone healing

Cifreda, Victor; Fidalgo-Pereira, Rita; Henriques, Bruno; Teughels, Wim; Özcan, Mutlu; Souza, Júlio C. M.

http://hdl.handle.net/10400.14/54141

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Authors

Cifreda, Victor

Fidalgo-Pereira, Rita

Abstract(s)

Purpose of the Review: The purpose of this study was to perform a scoping review on the comparison between tooth-derived matrix and demineralized bovine bone mineral (DBBM) granules for enhanced bone healing. Recent Findings: Previous studies reported micro-scale pores in dentin-matrix granules due to the remnant dentin that promote the adsorption of proteins and bioactive molecules. It should be highlighted the remnant dentin is an intrinsic source of collagen and growth factors such as TGF-1, BMP-2, VEGF, and PDGF. The DBBM showed macro-scale interconnected pores which enhances the adhesion of cells and formation of new blood vessels. DBBM also revealed a porosity of around 80% and a lower resorption rate when compared to tooth-derived granules. On in vivo models, dentin-matrix granules induced quite similar results for bone growth when compared to grafting with DBBM as confirmed by histological analyses. Summary: The dentin-derived matrix granules showed morphological aspects and chemical composition suitable for enhancing bone repair comparable to the effects of deproteinized bovine bone mineral granules. The adequate space among particles and size of pores plays a key role in the events of bone formation since the protein adsorption towards the bone growth. Also, a well-adjusted content of DBBM and dentin-derived granules in the mixture maintains the bone volume over the bone healing. Thus, autologous dentin-derived granules are alternative materials for bone healing without any adverse inflammatory reactions.