Browsing by Issue Date, starting with "2025-12-01"
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- Understanding the effect of the caring dimension of PYD on depression: the role of positive and negative affect regulation strategies in Spanish emerging adultsPublication . Gomez-Baya, Diego; Matos, Margarida Gaspar de; Wiium, NoraBackground: Positive Youth Development (PYD) has been associated with positive results in the transition to adulthood. Within the 5Cs model of PYD, the Caring dimension has been defined as the ability to feel sympathy and empathy towards others. However, the literature has shown some controversial results on the role of Caring in the psychological adjustment of young people. The aim of this study was to analyze the mediating role of strategies for coping with negative affect (i.e., distraction and depressive rumination) and strategies for coping with positive affect (i.e., dampening and positive rumination) in the relationship between Caring and depressive symptoms. We examined gender differences as well. Methods: A cross-sectional self-report study was carried out in 2021, with a sample of 1,040 young people (75.5% females; Age range = 18–28; Mage = 20.47, SD = 3.08), enrolled at 11 universities in Spain. Multiple partial mediation analysis was performed to examine the mediation of responses to positive and negative affect in the relationship between Caring and depression, and a path analysis was developed to integrate gender effects. Results: The results indicated that Caring was positively associated with more depressive symptoms through maladaptive affect responses, i.e., more depressive rumination, more inhibition of positive affect, less distraction and less positive rumination. On the contrary, a more adaptive regulation of the affect was associated with less depression. Gender differences were observed, where women scored higher in Caring, depressive rumination and dampening. Discussion: Some practical implications may be derived from these results. The role of Caring as an expression of sympathy and empathy can have a protective effect on psychological adjustment through the use adaptive skills to manage positive and negative affect. Programs integrating Caring dimension of PYD and emotional regulation skills training should be designed in university context, so that psychological adjustment can be maximized among university students and that the students, especially, females can be able to care for others as well as themselves.
- Comparison between tooth-derived matrix and DBBM granules on an enhanced bone healingPublication . Cifreda, Victor; Fidalgo-Pereira, Rita; Henriques, Bruno; Teughels, Wim; Özcan, Mutlu; Souza, Júlio C. M.Purpose of the Review: The purpose of this study was to perform a scoping review on the comparison between tooth-derived matrix and demineralized bovine bone mineral (DBBM) granules for enhanced bone healing. Recent Findings: Previous studies reported micro-scale pores in dentin-matrix granules due to the remnant dentin that promote the adsorption of proteins and bioactive molecules. It should be highlighted the remnant dentin is an intrinsic source of collagen and growth factors such as TGF-1, BMP-2, VEGF, and PDGF. The DBBM showed macro-scale interconnected pores which enhances the adhesion of cells and formation of new blood vessels. DBBM also revealed a porosity of around 80% and a lower resorption rate when compared to tooth-derived granules. On in vivo models, dentin-matrix granules induced quite similar results for bone growth when compared to grafting with DBBM as confirmed by histological analyses. Summary: The dentin-derived matrix granules showed morphological aspects and chemical composition suitable for enhancing bone repair comparable to the effects of deproteinized bovine bone mineral granules. The adequate space among particles and size of pores plays a key role in the events of bone formation since the protein adsorption towards the bone growth. Also, a well-adjusted content of DBBM and dentin-derived granules in the mixture maintains the bone volume over the bone healing. Thus, autologous dentin-derived granules are alternative materials for bone healing without any adverse inflammatory reactions.
- Oral health in inflammatory bowel disease: the overlooked impact and the potential role of salivary calprotectinPublication . Rodrigues, Cláudio; Gomes, Ana T. P. C.; Leal, Joana; Pereira, Pedro; Lopes, Pedro C.; Mendes, Karina; Correia, Maria J.; Veiga, Nélio; Rosa, Nuno; Soares, Caroline; Ministro, PaulaBackground: Inflammatory Bowel Disease (IBD), a chronic condition characterized by gastrointestinal inflammation, is influenced by genetic and environmental factors. Emerging evidence suggests a “mouth-gut axis,” with the oral cavity reflecting extra-intestinal manifestations of IBD. This study evaluated the oral health status of IBD patients and the potential of salivary calprotectin (SCP) as a biomarker for assessing IBD activity and oral health. Methods: Oral health was assessed in 100 IBD patients [60 with Crohn’s disease (CD) and 40 with ulcerative colitis (UC)] and 14 controls. Evaluations included the Decayed, Missing, and Filled Teeth (DMFT) Score, Periodontal Diagnosis and the need for dental or prosthetic treatment. Saliva and stool samples were collected to measure SCP and faecal calprotectin (FCP) levels using the Elia Calprotectin 2 Test. IBD activity was evaluated with FCP, the Harvey-Bradshaw Index for CD, and the Partial Mayo Score for UC. Results: The DMFT index mean was comparable between IBD patients (mean 7.99, SD 7.73) and controls (mean 10.00, SD 6.49). However, periodontal disease was significantly more prevalent in IBD patients (57% in CD, 70% in UC) than in controls (29%), with severe cases (stages III/IV) more frequent in IBD. Additionally, 89% of IBD patients required dental treatment, and 39% needed prosthetic rehabilitation. SCP levels showed no significant correlation with disease activity or oral health status, while FCP correlated with C-reactive protein and erythrocyte sedimentation rate. Conclusions: This study underscores the need for improved oral health management in IBD patients and suggests that SCP may not be a reliable biomarker for monitoring IBD or periodontal disease.