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Authors
Abstract(s)
Introdução
Os implantes dentários representam atualmente uma das alternativas mais
seguras para a substituição dos dentes em falta, quando existe o correto
diagnóstico e indicação clínica. Entretanto são descritas algumas complicações
relacionadas com a colocação de implantes, como por exemplo a doença periimplantar, que é a alteração patológica inflamatória dos tecidos que rodeiam um
implante. Dentro do conceito de doença peri-implantar, a peri-implantite, se
reflete um quadro clínico no qual, juntamente com a reação inflamatória da
mucosa peri-implantar, há uma perda de suporte ósseo para o implante, que é
clínica e radiograficamente evidente. Portanto, o objetivo deste projeto de
investigação foi determinar a eficácia da PDT (terapia fotodinâmica) como uma
solução sustentável para o tratamento da peri-implantite através da utilização
porfirinas como fotossensibilizadores e fotopolimerizador como fonte de luz.
Métodos
Foi realizado um estudo in vitro para avaliar o efeito antimicrobiano, da PDT,
utilizando o sal dissódico da ProtoporfirinaIX (Proto IX) como um
fotossensibilizador, e de uma fonte de luz denominada fotopolimerizador.
Resultados
O protocolo proposto que indica a realização da PDT usando ProtoIX e
fotopolimerizador mostrou ser eficaz na fotoinativação de Cândida albicans e
Enterococcus faecalis. Apesar das taxas de inativação tenham sido mais baixas
que a PDT convencional, os resultados desse estudo mostraram que também é
possível inativar estes dois microrganismos periodontopatogénicos.
Conclusões
Conclui-se que existe uma abordagem terapêutica eficaz para tratar a periimplantite a partir da PDT utilizando porfirinas comerciais, já aprovadas para uso
clínico, como fotosensibilizador, e fonte de luz azul proveniente de um aparelho
de fotopolimerizador. Como a luz azul é um equipamento disponível em todas as
práticas dentárias, o desenvolvimento deste protocolo pode ser facilmente
implementado de uma forma mais viável nas clínicas dentárias, sem a
necessidade de investir em novos dispositivos tecnológicos.
Introduction Dental implants are currently one of the safest alternatives for the replacement of missing teeth, when there is a correct diagnosis and clinical indication. However, some complications related to implant placement are described. Periimplant disease is the inflammatory pathological alteration of the tissues surrounding a loaded implant and is frequent in oral and facial Implantology. Within the concept of peri-implant disease, two entities are described: mucositis and peri-implantitis. The peri-implantitis reflects a clinical picture in which, along with the inflammatory reaction of the peri-implant mucosa, there is a loss of bone support for the implant, which is clinically and radiologically evident. Therefore, the objective of this research project is to determine the effectiveness of Photodynamic therapy (PDT) (as a sustainable solution for the treatment of periimplantitis through the use of porphyrins as photosensitizers and light-curing as light source. Methods An in vitro study was carried out to evaluate the antimicrobial effect, to evaluate the effects of PDT using the disodium salt of Protoporphyrin IX (Proto IX) as a photosensitizer and the dental curing light as light source. Results The adapted protocol of the PDT using ProtoIX and the dental curing light showed to be effective in the photoinactivation of C. albicans and E. faecalis. Despite lower inactivation rates, PDT studies on implants showed that it is also possible to inactivate these two periodontopathogenic microorganisms. Conclusions In this work we demonstrated that there is an effective therapeutic approach to treat periimplantitis from PDT using commercial porphyrins already approved for clinical use as a photosensitizer and blue light source from a dental curing light. This blue light from a photopolymerizer is available in all dental clinics, the development of this protocol can be easily implemented in all dental clinics, without the need to invest in new technological devices.
Introduction Dental implants are currently one of the safest alternatives for the replacement of missing teeth, when there is a correct diagnosis and clinical indication. However, some complications related to implant placement are described. Periimplant disease is the inflammatory pathological alteration of the tissues surrounding a loaded implant and is frequent in oral and facial Implantology. Within the concept of peri-implant disease, two entities are described: mucositis and peri-implantitis. The peri-implantitis reflects a clinical picture in which, along with the inflammatory reaction of the peri-implant mucosa, there is a loss of bone support for the implant, which is clinically and radiologically evident. Therefore, the objective of this research project is to determine the effectiveness of Photodynamic therapy (PDT) (as a sustainable solution for the treatment of periimplantitis through the use of porphyrins as photosensitizers and light-curing as light source. Methods An in vitro study was carried out to evaluate the antimicrobial effect, to evaluate the effects of PDT using the disodium salt of Protoporphyrin IX (Proto IX) as a photosensitizer and the dental curing light as light source. Results The adapted protocol of the PDT using ProtoIX and the dental curing light showed to be effective in the photoinactivation of C. albicans and E. faecalis. Despite lower inactivation rates, PDT studies on implants showed that it is also possible to inactivate these two periodontopathogenic microorganisms. Conclusions In this work we demonstrated that there is an effective therapeutic approach to treat periimplantitis from PDT using commercial porphyrins already approved for clinical use as a photosensitizer and blue light source from a dental curing light. This blue light from a photopolymerizer is available in all dental clinics, the development of this protocol can be easily implemented in all dental clinics, without the need to invest in new technological devices.
Description
Keywords
Porfirinas Peri-implantite Terapia fotodinâmica antimicrobiana Fotopolimerizador Porphyrins Perimplantitis Antimicrobial photodynamic therapy Dental curing light