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Funcionalização de estruturas têxteis com aditivos naturais para materiais de penso desbridantes
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| 17.36 MB | Adobe PDF |
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Abstract(s)
O desbridamento de uma ferida é uma das etapas mais importantes no processo de cicatrização. Os métodos mais utilizados atualmente, como o desbridamento mecânico, autolítico ou até mesmo enzimático ou cirúrgico, apresentam várias problemáticas associadas, tais como o aparecimento de danos nos tecidos adjacentes, o seu elevado custo, e o trauma para o paciente. A funcionalização de estruturas têxteis com aditivos naturais representa uma alternativa promissora para o desenvolvimento de materiais de penso mais eficazes e sustentáveis. Vários estudos têm demonstrado que a utilização de substâncias naturais pode reduzir o risco de reações alérgicas e efeitos colaterais adversos em comparação com o uso de aditivos químicos. O óleo de melaleuca tem sido um aditivo natural amplamente estudado para o auxílio na cicatrização de feridas, devido às suas propriedades antibacterianas e anti-inflamatórias. Este aditivo foi explorado neste trabalho, sendo a sua ancoragem ao substrato têxtil apoiada pelo uso de uma matriz de origem natural, o alginato, selecionado pelas suas propriedades absorventes e elevada biocompatibilidade. Estes aditivos foram os escolhidos para este trabalho com o principal objetivo de os incorporar em material de penso têxteis, avaliando a sua possível utilização no desbridamento de uma ferida. Através da dispersão do óleo numa solução aquosa de alginato pretendeu-se obter uma impregnação homogénea nas estruturas têxteis e uma libertação mais controlada. Foi realizado um estudo de libertação dependente do pH para analisar a libertação específica nos diferentes microambientes das feridas. Os substratos têxteis foram impregnados com os aditivos pela tecnologia de Foulard, sendo esta otimizada por forma a obter-se um bom pick-up dos aditivos, considerando a aplicação pretendida (uso do material ainda húmido no desbridamento). Os resultados demonstraram que a libertação do óleo de melaleuca é mais rápida a pH 8,7, com uma concentração de 30% deste óleo. Estes resultados foram de encontro ao pretendido, ocorrendo uma maior libertação do óleo nas feridas crónicas, possuindo estas um pH mais alcalino.
Wound debridement is one of the most important stages in the healing process. The most widely used methods today, such as mechanical, autolytic or even enzymatic or surgical debridement, present several associated problems, such as the appearance of damage to adjacent tissues, their high cost, and trauma to the patient. Functionalizing textile structures with natural additives represents a promising alternative for developing more effective and sustainable dressing materials. Several studies have shown that the use of natural substances can reduce the risk of allergic reactions and adverse side effects compared to the use of chemical additives. Tea tree oil has been a widely studied natural additive for aiding wound healing, due to its antibacterial and anti-inflammatory properties. This additive was explored in this study, and its anchoring to the textile substrate was supported by the use of a matrix of natural origin, alginate, selected for its absorbent properties and high biocompatibility. These additives were chosen for this work with the main aim of incorporating them into textile dressing material, assessing their possible use in wound debridement. By dispersing the oil in an aqueous alginate solution, the aim was to achieve homogeneous impregnation of the textile structures and a more controlled release. A pH-dependent release study was carried out to analyze the specific release in different wound microenvironments. The textile substrates were impregnated with the additives using Foulard technology, which was optimized in order to obtain a satisfactory pick-up of the additives, considering the intended application (use of the material while it was still wet for debridement). The results showed that the release of tea tree oil is faster at pH 8.7, with an oil concentration of 30%. These results were as intended, with greater oil release occurring in chronic wounds, which possess a more alkaline pH level.
Wound debridement is one of the most important stages in the healing process. The most widely used methods today, such as mechanical, autolytic or even enzymatic or surgical debridement, present several associated problems, such as the appearance of damage to adjacent tissues, their high cost, and trauma to the patient. Functionalizing textile structures with natural additives represents a promising alternative for developing more effective and sustainable dressing materials. Several studies have shown that the use of natural substances can reduce the risk of allergic reactions and adverse side effects compared to the use of chemical additives. Tea tree oil has been a widely studied natural additive for aiding wound healing, due to its antibacterial and anti-inflammatory properties. This additive was explored in this study, and its anchoring to the textile substrate was supported by the use of a matrix of natural origin, alginate, selected for its absorbent properties and high biocompatibility. These additives were chosen for this work with the main aim of incorporating them into textile dressing material, assessing their possible use in wound debridement. By dispersing the oil in an aqueous alginate solution, the aim was to achieve homogeneous impregnation of the textile structures and a more controlled release. A pH-dependent release study was carried out to analyze the specific release in different wound microenvironments. The textile substrates were impregnated with the additives using Foulard technology, which was optimized in order to obtain a satisfactory pick-up of the additives, considering the intended application (use of the material while it was still wet for debridement). The results showed that the release of tea tree oil is faster at pH 8.7, with an oil concentration of 30%. These results were as intended, with greater oil release occurring in chronic wounds, which possess a more alkaline pH level.
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Keywords
Desbridamento Óleo de melaleuca Impregnação Libertação Debridement Tea tree oil Impregnation Release
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