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Advisor(s)
Abstract(s)
A deteção de biomarcadores na saliva, proteínas que estão associadas
a fenótipos de patologias específicas, apresenta-se como uma área de
intervenção diagnóstica pouco estudada na atualidade.
Foi objetivo deste estudo de acordo com os dados de proteómica/
estudos dirigidos depositados no OralCard referentes a patologias orais e
sistémicas:
- Realizar uma análise crítica dos biomarcadores até agora propostos;
- Identificar que proteínas podem vir a constituir potenciais novos
biomarcadores.
A organização das proteínas exclusivas e identificadas como estando
presentes e/ou alteradas em doenças orais e sistémicas de acordo com a
ontologia “immune system process” e “cell death” foram submetidas a um
estudo de acordo com as suas funções biológicas específicas nestas
ontologias, realizando-se uma análise tanto aos biomarcadores sugeridos
como a novas propostas de biomarcadores.
Foram sugeridas neste estudo proteínas que apresentam valores de
quantificação em saliva e que são passíveis de serem integradas em estudos
para validação de biomarcadores, pois são proteínas com significado funcional
em patologias específicas e que contribuem para processos moleculares
alterados subjacentes a cada patologia. Foram também sugeridos novos
estudos de quantificação para biomarcadores já sugeridos e com falta de
dados de quantificação
The detection of biomarkers in saliva, proteins that are associated with specific phenotypes of pathologies, presents itself as an area of diagnostic intervention without much studies. Using the proteomic data / directed studies deposited in OralCard on oral and systemic diseases the primary goals of this study were:: - To conduct a critical analysis of biomarkers already proposed; - To identify proteins that may prove to be potential new biomarkers. The organization of the proteins exclusively identified as being present and / or altered in oral and systemic diseases according to the ontologies “immune system process” and “cell death” were submitted to the study of their specific biological functions in these ontologies, in order to make an analysis of both previously suggested biomarkers and biomarkers to be proposed. This study allowed to suggest proteins which contain regulation values in Whole Saliva and which are likely to become part of biomarker validation’s studies, because they have functional meaning in specific pathologies and contribute to a better characterization of the underlying molecular processes for each pathology. This study also allowed the suggestion of more regulation studies for the previously suggested biomarkers without regulation data.
The detection of biomarkers in saliva, proteins that are associated with specific phenotypes of pathologies, presents itself as an area of diagnostic intervention without much studies. Using the proteomic data / directed studies deposited in OralCard on oral and systemic diseases the primary goals of this study were:: - To conduct a critical analysis of biomarkers already proposed; - To identify proteins that may prove to be potential new biomarkers. The organization of the proteins exclusively identified as being present and / or altered in oral and systemic diseases according to the ontologies “immune system process” and “cell death” were submitted to the study of their specific biological functions in these ontologies, in order to make an analysis of both previously suggested biomarkers and biomarkers to be proposed. This study allowed to suggest proteins which contain regulation values in Whole Saliva and which are likely to become part of biomarker validation’s studies, because they have functional meaning in specific pathologies and contribute to a better characterization of the underlying molecular processes for each pathology. This study also allowed the suggestion of more regulation studies for the previously suggested biomarkers without regulation data.
Description
Keywords
Biomarcador Proteoma OralCard Saliva Análise funcional Biomarker Proteome Functional analysis