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- Sugarcane bagasse as a sustainable source of bioactive Xylo-Oligosaccharides: a comparative study with commercial XOSPublication . Tresmondi, Marina de Lima; Anthero, Ana Gabriela S.; Costa, Eduardo Manuel; Pintado, Maria Manuela; Goldbeck, RosanaINTRODUCTION Xylo-oligosaccharides (XOS) are non-digestible, low-calorie carbohydrates obtained from xylan-rich materials, including agro-industrial residues such as rice husk, corn cob, and sugarcane bagasse. Although XOS are already produced commercially, extensive research continues to explore different chemical, physicochemical, and enzymatic hydrolysis routes to produce XOS with controlled purity and structure. These differences strongly affect their functional properties, including antioxidant activity and ?-glucosidase inhibition, as well as their potential use as sugar substitutes and functional food ingredients. OBJECTIVE To assess and compare the functional properties of commercial XOS (XC) and XOS hydrolyzed from sugarcane bagasse (XSCB) by quantifying their phenolic compounds, antioxidant capacity, and ?-glucosidase inhibition.
- Nutritional and phytochemical profiling of grape by-products: toward high-value bioactive extractsPublication . Souza, Hiléia K. S.; Fernandes, Ana; Magalhães, Daniela; Vilas-Boas, Ana A.; Melo, Adma; Campos, Débora A.; Pintado, ManuelaGrape by-products, such as skins and seeds generated during winemaking, represent a valuable source of bioactive compounds and dietary fiber. These residues are rich in phenolics—particularly anthocyanins—with recognized antioxidant, antimicrobial, and anti-inflammatory activities. Their valorization aligns with circular economy principles, promoting waste reduction and the development of sustainable ingredients. The exploitation of these materials for food, nutraceutical, and packaging applications provides an opportunity to replace synthetic additives with natural alternatives. The main objective of this work was to characterize and valorize grape by-products as natural sources of bioactive compounds and antioxidants for sustainable industrial applications. The NOVAPACK Project aims to integrate grape by-products into sustainable value chains through their physicochemical characterization and the extraction of bioactive compounds.
- Preliminary evaluation of decolourisation of Procion and Everdirect dyes by yeastsPublication . Mendes, Marta; Moreira, Patrícia; Castro, Paula; Pintado, ManuelaIntroduction: Environmental pollution is one of the most important problems of actuality. The textile sector is a large and worldwide business and the most important in many countries. However, besides the high economic value that generates, it produces high volumes of effluents due to the large quantities of water used in fabric processing. This causes an enormous environmental problem concerning the contamination of water from rivers due to the discharge of effluents containing a wide range of dyes. These dyes are persistent in water, resistant to biodegradation, interfere with photosynthesis processes and are responsible for toxicity, carcinogenic and mutagenic effects to the aquatic life. The aim of this work was to evaluate the ability of selected yeast strains to decolourise specific dyes frequently used in the textile industry. Methods: Previously selected yeasts were tested to their ability to decolourise dyes commonly used in textile industries. Reactive dyes Red Procion HE 4R, Yellow Procion H, Navy Procion HEXL and direct dye Yellow Everdirect Supra RL, commonly used in cotton fibers, were selected for this work. Selected yeasts strains named 1a., 1b. and 1c. were cultivated in NDM liquid medium supplemented with 100 mg/L of each dye, in a 24 well microplate that was incubated at 25 ºC for 48 h and 100 rpm. Decolourisation was observed by naked eye. The yeast’s ability to decolourise dyes in a solid medium was also tested using NSDM medium supplemented with 100 mg/L of dye and plates were incubated at 25 ºC for 48 h. Decolourisation halos around colonies were observed as well as the colour of the colonies themselves. Conclusions: Strain 1c. was the only effective yeast strain with regards to the ability to decolourise the dyes tested. In these conditions, strain 1a. and 1b. are only able to absorb the dyes tested. Strain 1c. seems to be the only one that is able to perform true decolourisation.
- Biocatalytic nanobots: enhancing reactive oxygen species neutralisation for targeted therapy in inflammatory bowel diseasePublication . Sousa, Ana Sofia; Mayer, André; Reis, Celso A.; Pintado, Maria Manuela; Coscueta, Ezequiel R.Background & idea: Inflammatory bowel disease (IBD) is marked by chronic intestinal inflammation and an overproduction of reactive oxygen species (ROS) within the gastrointestinal mucosa. Elevated ROS levels contribute to tissue damage and impair mucosal healing, thereby intensifying the inflammatory process. Conventional treatments, such as corticosteroids and immunosuppressants, primarily target systemic inflammation but are limited in addressing the localized oxidative stress characteristic of IBD. To overcome these limitations, our study introduces a polymeric biocatalytic nanobot (NB) system designed to combine efficient propulsion with ROS neutralisation. The NB is built around a chitosan core with mucoadhesive properties, which promotes prolonged retention at inflamed mucosal surfaces and may also enhance the delivery of bioactive compounds.
- Development of a biocatalytic polymeric nanobot core for applications in inflammatory bowel diseasePublication . Sousa, Ana Sofia; Mayer, André; Reis, Celso A.; Pintado, Maria Manuela; Coscueta, Ezequiel R.
- Design and characterization of biopolymer-based core–shell particles for sustained release of adenosine in tissue regenerationPublication . Bernardes, Beatriz G.; Sousa, Clara; Sellitto, Maria Rosaria; Iglesias-Mejuto, Ana; Gaudio, Pasquale del; Costa, Raquel; García-González, Carlos A.; Oliveira, Ana Leite
- Smart sampling procedure for metal ions assessment in dynamic water systemsPublication . Mesquita, Raquel B. R.; Pereira, Mafalda G.; Rodrigues, Francisco A. P.; Melo, Maria M. P.; Ferreira, Francisca T. S. M.; Ribas, Tânia C. F.; Rangel, António O. S. S.
- Evaluation of decolourisation of textile dyes by selected yeastsPublication . Mendes, Marta; Moreira, Patrícia; Castro, Paula; Pintado, Manuela
- Design and characterization of biopolymer-based core–shell particles for sustained release of adenosine in tissue regenerationPublication . Bernardes, Beatriz G.; Sousa, Clara; Sellitto, Maria Rosaria; Iglesias-Mejuto, Ana; Gaudio, Pasquale del; Costa, Raquel; García-González, Carlos A.; Oliveira, Ana LeiteThe treatment of chronic wounds remains a formidable challenge in regenerative medicine, necessitating multifunctional biomaterials capable of modulating inflammation, promoting angiogenesis, and enabling sustained drug delivery [1]. This study presents a novel class of core–shell aerogel particles engineered from silk fibroin (SF), silk sericin (SS), and alginate (ALG), designed for the controlled release of adenosine (ADO)—a nucleoside with anti-inflammatory and pro-regenerative properties [2]. Using coaxial prilling and supercritical CO? drying, two architectures were fabricated: SF/ALG cores enveloped by ALG or ALG/SS shells.
- Comparative in silico docking of bioactive peptides across the gut-skin axis: a systems approach to psoriasis modulation via the host-microbe interactionsPublication . Silva, Isa; Lambert, Jo L. W.; Pintado, Manuela; Coscueta, Ezequiel R.Introduction: Psoriasis and inflammatory bowel disease (IBD) are chronic immune-mediated disorders sharing epithelial barrier dysfunction, dysbiosis, and sustained pro-inflammatory signaling. The gut–skin axis represents a network of host–microbe interactions, where microbial metabolites and immune responses shape inflammation in both intestinal and cutaneous environments.1 Bioactive peptides (BPeps) from natural sources are promising immunomodulators that may restore barrier integrity and attenuate key pathways such as NF-?B, JAK/STAT, and MAPK.2 Given this complex interplay, molecular docking was applied as an in silico strategy to prioritize peptide–protein interactions for in vitro validation.