Percorrer por autor "Silva, Rui"
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- Alcohol use and attitudes thought pregnancy and motherhood during pregnancy in a group of Portuguese womenPublication . Xavier, Maria Raul; Dias, Pedro; Veiga, Elisa; Silva, Rui; Gordinho, CláudiaIntroduction Alcohol during pregnancy is a significant health problem with negative prenatal, neonatal and later outcomes. In spite of increase consumption of Portuguese women, data about alcohol during pregnancy is scarce. The objective is to describe patterns of alcohol consumption and related attitudes though pregnancy in group of Portuguese pregnant women. Method The study group includes 222 women seeking prenatal care (childbirth preparation courses) in public health services in the north of Portugal. After a presentation of the aims of the study, and followed a written informed consent, pregnant women fulfil the Alcohol Use Disorders Identification Test - AUDIT (Babor, 2001) and the Pregnancy and Maternal Attitudes Scale - PMAS (Xavier, Paul & Sousa, 2001). Results Data concerning descriptive analysis of the group will be present. We found that more than 20% of the pregnant women continue to drink during pregnancy. Among this group who reported consumption, a majority (82.6%) reported a consumption frequency of once/month or less and 17.4% reported use two or four times/month. No one reported a superior amount. Results also indicated that consumptions are related to differences on some dimensions of the psychological experience of pregnancy (PMAS: The Imagined Child and Body Image and Dependency subscales). Conclusions Despite WHO, European and Portuguese governmental concerns and recommendations, more than 20% of pregnant women continue to drink. If women were not pregnant, this data corresponds to level risk 1- abstinent and low risk drinkers, but during pregnancy must be viewed with concern and indicate a continued need for research.
- An SNF2 helicase-like protein links mitotic transcription termination to sister chromatid resolutionPublication . Carmo, Catarina; Coelho, João; Silva, Rui; Tavares, Alexandra; Boavida, Ana; Gaetani, Paola; Martinho, Rui Gonçalo; Oliveira, Raquel A.Mitotic chromatin is largely assumed incompatible with transcription due to changes in the transcription machinery and chromosome architecture. However, the mechanisms of mitotic transcriptional inactivation and their interplay with chromosome assembly remain largely unknown. By monitoring ongoing transcription in Drosophila early embryos, we reveal that eviction of nascent mRNAs from mitotic chromatin occurs after substantial chromosome compaction and is not promoted by condensin I. Instead, we show that the timely removal of transcripts from mitotic chromatin is driven by the SNF2 helicase-like protein Lodestar (Lds), identified here as a modulator of sister chromatid cohesion defects. In addition to transcriptional termination, we uncovered that Lds cooperates with Topoisomerase 2 to ensure efficient sister chromatid resolution and mitotic fidelity. We conclude that mitotic transcriptional termination is not a passive consequence of cell cycle progression and/or chromosome compaction but occurs via dedicated mechanisms with functional parallelisms to sister chromatid resolution.
- Attitudes about pregnancy and motherhood and alcohol consumption in a group of Portuguese pregnant womenPublication . Xavier, Maria Raúl; Dias, Pedro; Veiga, Elisa; Silva, Rui; Gordinho, Cláudia
- Ensino em nutrição: estudo sobre a realidade de enfermagemPublication . Teixeira, Abílio Cardoso; Oliveira, Margarida; Meireis, Paula; Silva, Rui; Magalhães, Bruno; Leite, Carlos; Alves, Paulo