Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/3298
Título: Antioxidant activity of chitooligosaccharides upon two biological systems: Erythrocytes and bacteriophages
Autor: Fernandes, João C.
Eaton, Peter
Nascimento, Henrique
Gião, Maria S.
Ramos, Óscar S.
Belo, Luís
Santos-Silva, Alice
Pintado, Manuela E.
Malcata, F. Xavier
Palavras-chave: AAPH
Hydrogen peroxide
Phage P22
Data: 2010
Editora: Elsevier
Citação: FERNANDES, João C...[et al.] - Antioxidant activity of chitooligosaccharides upon two biological systems: Erythrocytes and bacteriophages. Carbohydrate Polymers. ISSN 0144-8617. Vol. 79, n.º 4 (2010), p. 1101–1106
Resumo: Most of the reports to date on the antioxidant capacity of chitosans and chitooligosaccharides (COS) are based on strictly chemical methods. When studying antioxidants with potential in vivo applications, the method used to evaluate the antioxidant activity should be representative of the conditions in which the antioxidant might have a protective effect. In this work we evaluate the antioxidant activity of two COS mixtures and a low MW chitosan (LMWC) upon two biological oxidizable substrates – erythrocytes and phages, subjected to accelerated oxidation conditions. Our results suggest that COS/LMWC can be used as antioxidants in biological systems. All the tested compounds reduced either the hemolytic and DNA damage, by inhibiting H2O2- and AAPH-radicals. However, the results obtained for these biological assays did not reveal a dose dependence, contrary to the chemical assay, suggesting that the protective concentrations should be established, in order to prevent enhancement of the oxidative damage – i.e. a prooxidant effect.
URI: http://hdl.handle.net/10400.14/3298
Versão do Editor: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TFD-4XHM18K-5&_user=2460358&_coverDate=03%2F17%2F2010&_rdoc=43&_fmt=high&_orig=browse&_origin=browse&_zone=rslt_list_item&_srch=doc-info%28%23toc%235224%232010%23999209995%231591121%23FLA%23display%23Volume%29&_cdi=5224&_sort=d&_docanchor=&_ct=51&_acct=C000057417&_version=1&_urlVersion=0&_userid=2460358&md5=02bfcb6c1182b267722d2ca59d335ddf&searchtype=a
Aparece nas colecções:CBQF - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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