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Antioxidant activity of chitooligosaccharides upon two biological systems: erythrocytes and bacteriophages

2010Journal article Restricted access
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dc.contributor.authorFernandes, João C.
dc.contributor.authorEaton, Peter
dc.contributor.authorNascimento, Henrique
dc.contributor.authorGião, Maria S.
dc.contributor.authorRamos, Oscar. L.
dc.contributor.authorBelo, Luís
dc.contributor.authorSantos-Silva, Alice
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorMalcata, F. Xavier
dc.date.accessioned2010-11-04T17:09:46Z
dc.date.available2010-11-04T17:09:46Z
dc.date.issued2010
dc.description.abstractMost of the reports to date on the antioxidant capacity of chitosans and chitooligosaccharides (COS) are based on strictly chemical methods. When studying antioxidants with potential in vivo applications, the method used to evaluate the antioxidant activity should be representative of the conditions in which the antioxidant might have a protective effect. In this work we evaluate the antioxidant activity of two COS mixtures and a low MW chitosan (LMWC) upon two biological oxidizable substrates – erythrocytes and phages, subjected to accelerated oxidation conditions. Our results suggest that COS/LMWC can be used as antioxidants in biological systems. All the tested compounds reduced either the hemolytic and DNA damage, by inhibiting H2O2- and AAPH-radicals. However, the results obtained for these biological assays did not reveal a dose dependence, contrary to the chemical assay, suggesting that the protective concentrations should be established, in order to prevent enhancement of the oxidative damage – i.e. a prooxidant effect.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationFERNANDES, João C...[et al.] - Antioxidant activity of chitooligosaccharides upon two biological systems: Erythrocytes and bacteriophages. Carbohydrate Polymers. ISSN 0144-8617. Vol. 79, n.º 4 (2010), p. 1101–1106por
dc.identifier.doi10.1016/j.carbpol.2009.10.050
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/10400.14/3298
dc.identifier.wosWOS:000275220500042
dc.language.isoengpor
dc.publisherElsevierpor
dc.relationANTIOXIDANTS IN HERBAL TEAS AS FUNCTIONAL INGREDIENTS: EXTRACTION, CHARACTERIZATION, BIOAVAILABILITY, ACTIVITY AND APPLICATIONS
dc.subjectAAPHpor
dc.subjectHydrogen peroxidepor
dc.subjectErythrocytespor
dc.subjectPhage P22por
dc.subjectChitooligosaccharidespor
dc.titleAntioxidant activity of chitooligosaccharides upon two biological systems: erythrocytes and bacteriophagespor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleANTIOXIDANTS IN HERBAL TEAS AS FUNCTIONAL INGREDIENTS: EXTRACTION, CHARACTERIZATION, BIOAVAILABILITY, ACTIVITY AND APPLICATIONS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F31087%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F19601%2F2004/PT
oaire.citation.endPage1106
oaire.citation.issue4
oaire.citation.startPage1101
oaire.citation.titleCarbohydrate Polymers
oaire.citation.volume79
oaire.fundingStreamSFRH
person.familyNameFernandes
person.familyNameEaton
person.familyNameNascimento
person.familyNameRamos
person.familyNameBelo
person.familyNameSantos-Silva
person.familyNamePintado
person.familyNameMalcata
person.givenNameJoão
person.givenNamePeter
person.givenNameHenrique
person.givenNameOscar
person.givenNameLuís
person.givenNameAlice
person.givenNameMaria Manuela
person.givenNameFrancisco
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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