Orientador(es)
Resumo(s)
Bacteriophage/bacterium systems have been employed in the past in assays for virucidal activity. A
novel application of one such system is proposed here for the in vivo determination of antioxidant
capacity. It was shown that an antioxidant such as gallic acid can effectively protect against oxidative
damage brought about by H2O2sbut only within a narrow range of concentrations (i.e., from 250 to
500 mg L-1); ascorbic acid, on the other hand, did not exhibit any protective effect against H2O2.
Finally, neither ascorbic nor gallic acid demonstrated a virucidal effect. The P22/Salmonella
typhimurium model system thus proved to be useful in the assessment of antioxidant capacity in
vivo, at least using those two alternative model antioxidants.
Descrição
Palavras-chave
Ascorbic acid Gallic acid In vivo assessment
Contexto Educativo
Citação
Editora
American Chemical Society