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Stability of bioactive solid lipid nanoparticles loaded with herbal extracts when exposed to simulated gastrointestinal tract conditions

2015Journal article Restricted access
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dc.contributor.authorCampos, Débora A.
dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorSarmento, Bruno
dc.contributor.authorGomes, Ana Maria
dc.contributor.authorPintado, Maria Manuela
dc.date.accessioned2016-04-21T16:39:50Z
dc.date.available2016-04-21T16:39:50Z
dc.date.issued2015
dc.description.abstractSolid lipid nanoparticles (SLN) can be used as vehicles for phenolic compounds rich extracts. In the presentwork two types of waxes — witepsol and carnauba were tested for the first time in the production of solid lipid nanoparticles (WSLN and CSLN, respectively) loaded with sage and savoury extracts. Physical characterization and association efficiencies calculation were performed. Discrimination of loaded phenolic compounds from each extract was made using HPLC assays. Antioxidant activities of SLN were characterized using two different methods— ABTS and ORAC. Finally, the phenolic compound release profile from SLN and stabilitywhen exposed to simulated gastrointestinal tract (GIT) conditionswere also evaluated. Different phenolic compounds fromsage and savoury extracts were entrapped in SLN. The highest antioxidant activity was obtained for the SLN loaded with savoury extract. Stomach simulated condition provokes a partial release of rosmarinic acid from SLN, whereas at small intestine simulation step, all SLN showed a release of ca. 100%. Witepsol SLN were the ones that best maintained their physical integrity during digestion, showing to be the most stable vehicles for sage and savoury extracts. These SLN show to be suitable for the production of food functional ingredients bearing antioxidant activity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationCAMPO; Débora A. - Stability of bioactive solid lipid nanoparticles loaded with herbal extracts when exposed to simulated gastrointestinal tract conditions. Food Research International. ISSN 0963-9969. Vol. 78 (2015), p. 131–140pt_PT
dc.identifier.doi10.1016/j.foodres.2015.10.025
dc.identifier.eid84949194245
dc.identifier.eissn1873-7145
dc.identifier.issn0963-9969
dc.identifier.pmid28433274
dc.identifier.urihttp://hdl.handle.net/10400.14/19939
dc.identifier.wos000367774800016
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.subjectSLNpt_PT
dc.subjectHerbal extractspt_PT
dc.subjectDigestionpt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectRelease profilespt_PT
dc.titleStability of bioactive solid lipid nanoparticles loaded with herbal extracts when exposed to simulated gastrointestinal tract conditionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-ALI%2F117808%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FSAU%2FLA0002%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F71391%2F2010/PT
oaire.citation.endPage140
oaire.citation.startPage131
oaire.citation.titleFood Research International
oaire.citation.volume78
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
person.familyNameCampos
person.familyNameMadureira
person.familyNameSarmento
person.familyNameGomes
person.familyNamePintado
person.givenNameDébora
person.givenNameRaquel
person.givenNameBruno
person.givenNameAna Maria
person.givenNameMaria Manuela
person.identifierD-8675-2016
person.identifierM-4659-2013
person.identifier152609
person.identifier162628
person.identifier456608
person.identifier.ciencia-id1A16-FC5B-3468
person.identifier.ciencia-id1C14-25F8-CC07
person.identifier.ciencia-idE816-B6B0-06A5
person.identifier.ciencia-idAA12-BFC1-B2E3
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-0174-6640
person.identifier.orcid0000-0001-6596-1927
person.identifier.orcid0000-0001-5763-7553
person.identifier.orcid0000-0001-7883-2446
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridM-4659-2013
person.identifier.ridJ-6265-2013
person.identifier.ridB-9944-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55250923400
person.identifier.scopus-author-id8384097900
person.identifier.scopus-author-id57194334236
person.identifier.scopus-author-id57190668768
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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