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Advisor(s)
Abstract(s)
Solid lipid nanoparticles (SLN) can be used as vehicles for phenolic compounds rich extracts. In the presentwork
two types of waxes — witepsol and carnauba were tested for the first time in the production of solid lipid nanoparticles
(WSLN and CSLN, respectively) loaded with sage and savoury extracts. Physical characterization and
association efficiencies calculation were performed. Discrimination of loaded phenolic compounds from each
extract was made using HPLC assays. Antioxidant activities of SLN were characterized using two different
methods— ABTS and ORAC. Finally, the phenolic compound release profile from SLN and stabilitywhen exposed
to simulated gastrointestinal tract (GIT) conditionswere also evaluated. Different phenolic compounds fromsage
and savoury extracts were entrapped in SLN. The highest antioxidant activity was obtained for the SLN loaded
with savoury extract. Stomach simulated condition provokes a partial release of rosmarinic acid from SLN,
whereas at small intestine simulation step, all SLN showed a release of ca. 100%. Witepsol SLN were the ones
that best maintained their physical integrity during digestion, showing to be the most stable vehicles for sage
and savoury extracts. These SLN show to be suitable for the production of food functional ingredients bearing
antioxidant activity.
Description
Keywords
SLN Herbal extracts Digestion Antioxidant activity Release profiles
Pedagogical Context
Citation
CAMPO; Débora A. - Stability of bioactive solid lipid nanoparticles loaded with herbal extracts when exposed to simulated gastrointestinal tract conditions. Food Research International. ISSN 0963-9969. Vol. 78 (2015), p. 131–140
Publisher
Elsevier