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Advisor(s)
Abstract(s)
Introdução: A doença inflamatória intestinal (DII) é uma patologia inflamatória crónica do trato gastrointestinal, causada por uma resposta imune desregulada contra o microbioma intestinal comensal. Os objetivos da terapêutica são alcançar e manter a remissão da doença, prevenindo a sua progressão. A terapia nutricional está associada a alteração da microflora intestinal, aperfeiçoamento da função de barreira mucosa e efeito anti-inflamatório direto. Objetivo: Compreender o funcionamento e eficácia do tratamento nutricional na evolução da doença inflamatória intestinal. Revisão dos dados relativos a tratamento nutricional em idade pediátrica. Materiais e Métodos: Foi realizada uma revisão bibliográfica sobre o tema nas revistas científicas disponíveis online, reunindo e comparando os diferentes dados encontrados nas fontes de consulta. Resultados: Na indução da remissão da doença de Crohn ativa, a nutrição entérica exclusiva é tão efetiva como a corticoterapia. Na manutenção da remissão, os dados são escassos, mas a terapia nutricional parece diminuir o risco de recaídas. Conclusão: A nutrição entérica exclusiva é atualmente primeira linha para indução da remissão da doença de Crohn ativa e evidencia redução do risco de recaídas na manutenção da remissão em crianças com DII.
Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory pathology of the gastrointestinal tract caused by a dysregulated immune response against the commensal intestinal microbiome. The goals of therapy are to achieve and maintain disease remission, preventing its progression. Nutritional therapy is associated with changed intestinal microflora, improved mucosal barrier function and direct anti-inflammatory effect. Aim: To understand the functioning and effectiveness of nutritional treatment in the evolution of inflammatory bowel disease. Review of data on nutritional treatment in pediatric age. Materials and Methods: A bibliographic revision of scientific online reviews was conducted, gathering and comparing different sets of data found in the referred sources. Results: Exclusive enteral nutrition is as effective as corticosteroid therapy in inducing remission of active Crohn's disease. In maintaining remission, data are scarce, but nutritional therapy appears to decrease the risk of relapse. Conclusion: Exclusive enteral nutrition is currently the first line to induce remission of active Crohn's disease and shows a reduced risk of relapse in maintaining remission in children with IBD.
Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory pathology of the gastrointestinal tract caused by a dysregulated immune response against the commensal intestinal microbiome. The goals of therapy are to achieve and maintain disease remission, preventing its progression. Nutritional therapy is associated with changed intestinal microflora, improved mucosal barrier function and direct anti-inflammatory effect. Aim: To understand the functioning and effectiveness of nutritional treatment in the evolution of inflammatory bowel disease. Review of data on nutritional treatment in pediatric age. Materials and Methods: A bibliographic revision of scientific online reviews was conducted, gathering and comparing different sets of data found in the referred sources. Results: Exclusive enteral nutrition is as effective as corticosteroid therapy in inducing remission of active Crohn's disease. In maintaining remission, data are scarce, but nutritional therapy appears to decrease the risk of relapse. Conclusion: Exclusive enteral nutrition is currently the first line to induce remission of active Crohn's disease and shows a reduced risk of relapse in maintaining remission in children with IBD.
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Keywords
Doença inflamatória intestinal Terapia nutricional Nutrição pediátrica Inflammatory bowel diseases Nutritional therapy Pediatric nutrition