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What's a migraine day? Towards a consensus definition for clinical care and research - a Delphi panel-based study

2025-05-09Artigo de investigação Acesso aberto
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dc.contributor.authorLoose, Luna De
dc.contributor.authorPaemeleire, Koen
dc.contributor.authorDeligianni, Christina I.
dc.contributor.authorLampl, Christian
dc.contributor.authorUluduz, Derya
dc.contributor.authorTronvik, Erling
dc.contributor.authorCoppola, Gianluca
dc.contributor.authorSchytz, Henrik
dc.contributor.authorSchoenen, Jean
dc.contributor.authorRio, Margarita Sanchez del
dc.contributor.authorMartelletti, Paolo
dc.contributor.authorPozo-Rosich, Patricia
dc.contributor.authorGil-Gouveia, Raquel
dc.contributor.authorRyliskiene, Kristina
dc.contributor.authorSacco, Simona
dc.contributor.authorEkizoglu, Esme
dc.contributor.authorPetrušić, Igor
dc.contributor.authorFronczek, Rolf
dc.contributor.authorHolland, Phil
dc.contributor.authorReuter, Uwe
dc.contributor.authorGoadsby, Peter J.
dc.contributor.authorMaassenVanDenBrink, Antoinette
dc.contributor.authorVersijpt, Jan
dc.date.accessioned2026-05-25T15:26:36Z
dc.date.available2026-05-25T15:26:36Z
dc.date.issued2025-05-09
dc.description.abstractBackground Although guidelines for controlled trials have proposed a definition for a migraine day, substantial variability remains across clinical trials, highlighting the need for a universally adopted definition. Methods Through three survey rounds using an eDelphi method, a panel of 18 headache experts evaluated clinical scenarios to achieve consensus on a standardized definition of a migraine day. The first two rounds provided clearcut cases with the question whether a clinical scenario should be labelled as a migraine day and the third round proposed a migraine day definition. Consensus was predefined at 70% agreement. Results A consensus was reached on a proposed definition of a migraine day across three distinct situations: (1) without acute treatment, (2) with acute treatment, and (3) in the presence of aura. If untreated, a headache day can be labelled as a (probable) migraine day when the following criteria are met: headache lasting≥4 h having at least two out of four headache characteristics, regardless of the presence of any associated symptom or at least one out of four headache characteristics combined with one associated symptom. If treated, a headache day can be labelled as a migraine day when the following criterion is met: lasting≥30 min, regardless of drug (class) taken, the presence of any headache characteristic or associated symptom. In the presence of aura, a migraine day can be defined as any calendar day on which the following criterion is met: an aura, fulfilling the ICHD-3 criteria for migraine with aura, is experienced regardless of the presence of headache. Conclusions We suggest the Classification Committee considers this eDelphi survey based consensus definition as a possible definition both for clinical trials and clinical care in the new edition of the International Classification of Headache Disorderseng
dc.identifier.doi10.1186/s10194-026-02383-2
dc.identifier.eid105038599334
dc.identifier.otherb450f4ad-ad43-4a54-9a6d-875f33b876e3
dc.identifier.pmcPMC13169912
dc.identifier.pmid42106637
dc.identifier.urihttp://hdl.handle.net/10400.14/57837
dc.identifier.wos001764753700001
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBioMed Central Ltd.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectClassificationeng
dc.subjectIchdeng
dc.subjectMigraineeng
dc.subjectMigraine dayeng
dc.titleWhat's a migraine day? Towards a consensus definition for clinical care and research - a Delphi panel-based study
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume27
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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