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Fitness assessment in acute myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

2025-05-13Review article Open access
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorVenditti, Adriano
dc.contributor.authorPalmieri, Raffaele
dc.contributor.authorMaurillo, Luca
dc.contributor.authorRöllig, Christoph
dc.contributor.authorWierzbowska, Agnieszka
dc.contributor.authorde Leeuw, David
dc.contributor.authorEfficace, Fabio
dc.contributor.authorCurti, Antonio
dc.contributor.authorLam Ngai, Lok
dc.contributor.authorTettero, Jesse
dc.contributor.authorAdès, Lionel
dc.contributor.authorAlmeida, António
dc.contributor.authorBullinger, Lars
dc.contributor.authorDennis, Mike
dc.contributor.authorEsteve, Jordi
dc.contributor.authorFerrara, Felicetto
dc.contributor.authorHeuser, Michael
dc.contributor.authorHuls, Gerwin
dc.contributor.authorLübbert, Michael
dc.contributor.authorMehta, Priyanka
dc.contributor.authorMontesinos, Pau
dc.contributor.authorPabst, Thomas
dc.contributor.authorRécher, Christian
dc.contributor.authorRossi, Giuseppe
dc.contributor.authorRussell, Nigel
dc.contributor.authorSierra, Jorge
dc.contributor.authorStauder, Reinhard
dc.contributor.authorVey, Norbert
dc.contributor.authorWalter, Roland B.
dc.contributor.authorWang, Eunice
dc.contributor.authorNier, Samantha
dc.contributor.authorGarcez Martins, Carolina
dc.contributor.authorOssenkoppele, Gert
dc.date.accessioned2025-08-13T15:14:11Z
dc.date.available2025-08-13T15:14:11Z
dc.date.issued2025-05-13
dc.description.abstractFitness assessment in patients with acute myeloid leukemia (AML) is critical to deliver the right therapy to the right patient. Although several scoring systems are available to aid in determining fitness, the absence of validation studies has resulted in the lack of universally accepted assessment procedures. This limitation, combined with the increasing availability of novel agents expanding the spectrum of less-intensive options, has introduced additional complexity to the fitness assessment process. In this evolving context, fitness should reflect eligibility for a specific treatment among the several available, rather than a generic binary classification of eligibility for intensive chemotherapy. Moreover, the growing emphasis on patient-centered care, further highlights the importance of integrating quality of life, patient preferences, patient self-reported physical and social functioning status, social support, and early integration of palliative care into the assessment framework. A modern interpretation of fitness assessment should incorporate a comprehensive evaluation that extends beyond traditional clinical and biological disease characteristics. Thus, fitness assessment in patients with AML represents only 1 piece of a larger puzzle, encompassing the patient’s overall capacity to sustain and benefit from a specific therapeutic program.eng
dc.identifier.citationVenditti, A., Palmieri, R., Maurillo, L., & Röllig, C. et al. (2025). Fitness assessment in acute myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood advances, 9(9), 2207-2220. https://doi.org/10.1182/bloodadvances.2024013744
dc.identifier.doi10.1182/bloodadvances.2024013744
dc.identifier.eid105004265601
dc.identifier.issn2473-9529
dc.identifier.other7476b443-0c7e-471d-8575-2cc4e00a7b48
dc.identifier.pmid39913928
dc.identifier.urihttp://hdl.handle.net/10400.14/54556
dc.identifier.wos001487106000001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleFitness assessment in acute myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNeteng
dc.typereview article
dspace.entity.typePublication
oaire.citation.endPage2220
oaire.citation.issue9
oaire.citation.startPage2207
oaire.citation.titleBlood advances
oaire.citation.volume9
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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