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Advisor(s)
Abstract(s)
Background and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.
Description
Keywords
Fecal microbiota transplantation Carbapenamase-producing enterobacteriaceae Multidrug-resistant infections Decolonization Intestinal carriage
Pedagogical Context
Citation
Silva, J. C., Ponte, A., Mota, M., Pinho, R., Vieira, N., Oliveira, R., ... Edgar, A. (2020). Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae. Revista Espanola de Enfermedades Digestivas, 112(12), 925-928
Publisher
Sociedad Española de Patología Digestiva