Repository logo
 
Publication

Erythropoietin doping as cause of sudden death in athletes: an experimental study

2010Conference object Open access
Simple item page
dc.contributor.authorPiloto, N.
dc.contributor.authorTeixeira, H.M.
dc.contributor.authorTeixeira-Lemos, E.
dc.contributor.authorParada, B.
dc.contributor.authorGarrido, P.
dc.contributor.authorSereno, J.
dc.contributor.authorF. Pinto, A.F.
dc.contributor.authorCosta, Elísio
dc.contributor.authorBelo, L.
dc.contributor.authorSantos-Silva, A.
dc.contributor.authorPinto, R.
dc.contributor.authorCouceiro, P.
dc.contributor.authorNeto, P.
dc.contributor.authorXavier, F.
dc.contributor.authorCarvalho, L.
dc.contributor.authorTeixeira, F.
dc.contributor.authorReis, F.
dc.date.accessioned2011-07-01T15:29:41Z
dc.date.available2011-07-01T15:29:41Z
dc.date.issued2010
dc.description.abstractAims: To evaluate the cardiovascular (CV) effects of rhEPO treatment in rats under chronic aerobic exercise and to assess the probable cause of sudden death in one rat. Protocol: Male Wistar rats: control - sedentary; rhEPO - 50 IU/Kg/3xwk; swimming (EX) -1 hr, 3x/wk; EX+EPO. Hematology, catecholamines and serotonin, redox status and inflammation, were assessed. One rat of EX+EPO group suffered a sudden death episode. Results: rhEPO treatment in trained rats promoted several markers of increased CV risk. The sudden death rat tissues presented: lungs without signs of drowning; brain with vascular congestion; LV hypertrpphy and deregulations of cardiac fibers, together with a "cardiac liver", suggesting the hypothesis of heart failure as cause of death. Conclusion: The sudden death of a EX+EPO rat, due to a cardiac episode, together with the increased CV risk profile, strongly suggest a high life risk associated to the continuous rhEPO doping. The anatomo-pathological studies were determinant to establish the cause of death.por
dc.identifier.citationPILOTO, N… [et al.] - Erythropoietin doping as cause of sudden death in athletes: an experimental study. In Congresso da Academia Internacional de Medicina Legal, 21, Lisboa, Portugal, 28-30 de Maio de 2009 - VIEIRA, Duarte Nuno, coord… [et al.] - Acta Medicinae Legalis et Socialis. [S.l.] : Imprensa da Universidade de Coimbra/ Academia Internacional de Medicina Legal, 2010. ISBN: 978-989-26-0049-9. p. 267-274por
dc.identifier.urihttp://hdl.handle.net/10400.14/4632
dc.language.isoengpor
dc.publisherImprensa da Universidade de Coimbra / Academia Internacional de Medicina Legalpor
dc.subjectrhEPOpor
dc.subjectDopingpor
dc.subjectChronic aerobic exercisepor
dc.subjectSudden Deathpor
dc.titleErythropoietin doping as cause of sudden death in athletes: an experimental studypor
dc.typeconference object
dspace.entity.typePublication
person.familyNameBelo
person.givenNameLuís
person.identifier.ciencia-idC319-EED1-E15D
person.identifier.orcid0000-0002-3941-6850
person.identifier.ridK-5878-2013
person.identifier.scopus-author-id6602879850
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication3654b7b5-7ad2-4f2f-9114-93dc094f8e9e
relation.isAuthorOfPublication.latestForDiscovery3654b7b5-7ad2-4f2f-9114-93dc094f8e9e

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Acta Medicinae Legalis et Socialis 1.pdf
Size:
2.73 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.44 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCSE - Documentos de Conferências / Conference Objects