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Degradation of Fluoroquinolone Antibiotics and Identification of Metabolites/Transformation Products by LC-MS/MS

2013-06Conference object Open access
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dc.contributor.authorMaia, Alexandra S.
dc.contributor.authorRibeiro, Ana R.
dc.contributor.authorAmorim, Catarina L.
dc.contributor.authorBarreiro, Juliana C.
dc.contributor.authorCass, Quezia B.
dc.contributor.authorCastro, Paula M.L.
dc.contributor.authorTiritan, Maria E.
dc.date.accessioned2013-11-14T16:32:00Z
dc.date.available2013-11-14T16:32:00Z
dc.date.issued2013-06
dc.description.abstractAntibiotics are a therapeutic class widely found inenvironmental matrices and extensively studied due to its persistence and implications for multi-resistant bacteria development. Degradation of four fluoroquinolone antibiotics, namely Ofloxacin (OFL), Norfloxacin (NOR), Ciprofloxacin (CPF) and Moxifloxacin (MOX), at 10 mg L-1 using a mixed bacterial culture, was assessed for 60 days. The assays were followed by a developed and validated analytical method of HPLC with Fluorescence Detection using a Luna PFP (2) 3µm column. The optimized conditions allowed picturing metabolites/transformation products formation and accumulation during the process, stating an incomplete mineralization, also shown byfluoride release. OFL and MOX presented the highest (98.3%) and the lowest (80.5%) extent of degradation after 19 days of assay, respectively. Some of these intermediate compounds were identified by LCMS/MS in selected degradation samples. Most of the intermediates were already described as biodegradation and/or photodegradationproducts in different conditions, but new and/or unknown metabolites were also present.por
dc.identifier.citationMAIA, Alexandra S. [et al.] - Enantioselective Determination of Fluoxetine and Norfluoxetine in Wastewater. In 39th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Amsterdam, The Netherlands, 16-20 June 2013 – In HPLC 2013 - 39th International Symposium on High Performance Liquid Phase Separations and Related Techniques: Book of Abstracts, (2013) p.379por
dc.identifier.urihttp://hdl.handle.net/10400.14/13242
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectBiodegradationpor
dc.subjectFluoroquinolonespor
dc.subjectLC-MS/MSpor
dc.subjectMetabolitespor
dc.titleDegradation of Fluoroquinolone Antibiotics and Identification of Metabolites/Transformation Products by LC-MS/MSpor
dc.typeconference object
dspace.entity.typePublication
person.familyNameMaia
person.familyNameCastro
person.familyNameTiritan
person.givenNameAlexandra S.
person.givenNamePaula
person.givenNameMaria Elizabeth
person.identifier2013444
person.identifier1310409
person.identifier.ciencia-id6A15-F0A3-AEF2
person.identifier.ciencia-id7C1F-6C72-354A
person.identifier.ciencia-idD915-BFC0-FB3A
person.identifier.orcid0000-0002-4167-383X
person.identifier.orcid0000-0001-8841-6606
person.identifier.orcid0000-0003-3320-730X
person.identifier.ridM-8241-2013
person.identifier.ridK-9492-2014
person.identifier.scopus-author-id55332349300
person.identifier.scopus-author-id7102781782
person.identifier.scopus-author-id6602890981
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication56eedbbf-8105-4d55-bf1f-e38c62ed4da5
relation.isAuthorOfPublicationf2253992-dc8d-4042-9a0f-597ebcf0a1d6
relation.isAuthorOfPublication1ab8e8f5-cf82-4edd-89d8-46e5cca13e19
relation.isAuthorOfPublication.latestForDiscovery56eedbbf-8105-4d55-bf1f-e38c62ed4da5

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