Orientador(es)
Resumo(s)
A experiência científica indica que o estado de inflamação crónico tem um papel crucial na patogénese da disfunção metabólica relacionada com a obesidade. Este estudo tem como objetivo avaliar as alterações no processo inflamatório, metabolismo do ferro, eritropoiese, e perfil lipídico, associadas à perda de peso após cirurgia de banda gástrica.
Foram avaliados 46 doentes antes e 3 meses após cirurgia de banda gástrica. Foi efetuado um inquérito com registo dos dados antropométricos, índice de massa corporal (IMC) e registo da presença de comorbilidades. Foi ainda efetuado hemograma completo, doseamento do ferro sérico, ferritina, transferrina, proteína C reativa de alta sensibilidade (PCRas), colesterol total (CT), colesterol-LDL (colesterol lipoproteíco de baixa densidade), colesterol-HDL (colesterol lipoproteíco de alta densidade), e triglicerídeos (Tg).
Três meses após a cirurgia, este grupo de doentes apresentou uma diminuição significativa no peso e IMC, associado com uma diminuição do processo inflamatório (diminuição da PCRas, ferritina, contagem de neutrófilos, e da razão neutrófilo/linfócito), aumento do ferro disponível (aumento da saturação da transferrina, e tendência para aumento dos níveis de ferro sérico), diminuição da eritropoiese (diminuição na contagem de reticulócitos e índice de produção de reticulócitos) e diminuição significativa nos Tg e na razão Tg/HDL-c.
Os resultados obtidos demonstram diminuição significativa no processo inflamatório 3 meses após colocação de banda gástrica, associada à perda de tecido adiposo. Esta diminuição no processo inflamatório associa-se a uma mais eficiente absorção do ferro e aumento da sua disponibilidade para a eritropoiese. Em termos de perfil lipídico verificamos diminuição na concentração de Tg. Estas modificações sugerem benefícios da cirurgia de banda gástrica, nomeadamente na diminuição do risco de doença cardiovascular.
Accumulating evidence indicates that a state of chronic inflammation has a crucial role in the pathogenesis of obesity-related metabolic dysfunction. This study aims to evaluate changes in inflammatory process, iron metabolism, erythropoiesis and lipid profile associated with weight loss after gastric banding surgery. Forty six patients were evaluated before and 3 months after gastric banding surgery. A survey was conducted with recording of demographics, body mass index (BMI) and records the presence of co morbidities. Moreover, complete blood cell counts and serum levels of iron, ferritin, transferrin, high sensitivity C-reactive protein (hsCRP), total cholesterol, LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c) and triglycerides (TG) were performed. Three months after surgery our patients presented a significant decreased in weight and BMI, associated with a decreased in inflammatory process (decreased hsPCR, ferritin, neutrophil counts and neutrophil/lymphocyte ratio), increased iron availability (increase in transferrin saturation and a trend to higher iron serum levels), decreased erythropoisis (decreased in reticulocytes counts and reticulocyte production index) and significant decreased in TG and in Tg/HDL-cholesterol ratio. Our results showed a significant decrease in the inflammation process, 3 months after gastric banding surgery, which might be associated with adipose tissue loss. This decreased in the inflammatory process results in more efficient iron absorption and increasing iron availability for erythropoiesis. Moreover, we also found a decreased TG serum levels. These changes suggest benefits from gastric band surgery, including decreased risk of cardiovascular disease
Accumulating evidence indicates that a state of chronic inflammation has a crucial role in the pathogenesis of obesity-related metabolic dysfunction. This study aims to evaluate changes in inflammatory process, iron metabolism, erythropoiesis and lipid profile associated with weight loss after gastric banding surgery. Forty six patients were evaluated before and 3 months after gastric banding surgery. A survey was conducted with recording of demographics, body mass index (BMI) and records the presence of co morbidities. Moreover, complete blood cell counts and serum levels of iron, ferritin, transferrin, high sensitivity C-reactive protein (hsCRP), total cholesterol, LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c) and triglycerides (TG) were performed. Three months after surgery our patients presented a significant decreased in weight and BMI, associated with a decreased in inflammatory process (decreased hsPCR, ferritin, neutrophil counts and neutrophil/lymphocyte ratio), increased iron availability (increase in transferrin saturation and a trend to higher iron serum levels), decreased erythropoisis (decreased in reticulocytes counts and reticulocyte production index) and significant decreased in TG and in Tg/HDL-cholesterol ratio. Our results showed a significant decrease in the inflammation process, 3 months after gastric banding surgery, which might be associated with adipose tissue loss. This decreased in the inflammatory process results in more efficient iron absorption and increasing iron availability for erythropoiesis. Moreover, we also found a decreased TG serum levels. These changes suggest benefits from gastric band surgery, including decreased risk of cardiovascular disease