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Poly(l-lactide-co-caprolactone-co-glycolide)-based nanoparticles as delivery platform: effect of the surfactants on characteristics and delivery efficiency

2022-05-01Journal article Open access
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dc.contributor.authorRebanda, Magda M.
dc.contributor.authorBettini, Simona
dc.contributor.authorBlasi, Laura
dc.contributor.authorGaballo, Antonio
dc.contributor.authorRagusa, Andrea
dc.contributor.authorQuarta, Alessandra
dc.contributor.authorPiccirillo, Clara
dc.date.accessioned2022-05-18T15:58:22Z
dc.date.available2022-05-18T15:58:22Z
dc.date.issued2022-05-01
dc.description.abstractPolymeric nanoparticles made of the copolymer Poly(L-lactide-co-caprolactone-co-glycolide) were prepared using the solvent evaporation method. Two different surfactants, polyvinyl alcohol and dextran, and a mixture of the two were employed. The three types of nanoparticles were used as hosting carriers of two chemotherapeutic drugs, the hydrophilic doxorubicin and the hydrophobic SN-38. The morphostructural characterization showed similar features for the three types of nanoparticles, while the drug encapsulation efficiency indicated that the dextran-based systems are the most effective with both drugs. Cellular studies with breast cancer cells were performed to compare the delivery capability and the cytotoxicity profile of the three nanosystems. The results show that the unloaded nanoparticles are highly biocompatible at the administered concentrations and confirmed that dextran-coated nanoparticles are the most efficient vectors to release the two drugs, exerting cytotoxic activity. PVA, on the other hand, shows limited drug release in vitro, probably due to strong interactions with both drugs. Data also show the release is more efficient for doxorubicin than for SN-38; indeed, the doxorubicin IC50 value for the dextran-coated nanoparticles was about 35% lower than the free drug. This indicates that these nanocarriers are suitable candidates to deliver hydrophilic drugs while needing further modification to host hydrophobic molecules.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/nano12091550pt_PT
dc.identifier.eid85129125792
dc.identifier.issn2079-4991
dc.identifier.pmcPMC9103935
dc.identifier.pmid35564258
dc.identifier.urihttp://hdl.handle.net/10400.14/37631
dc.identifier.wos000795341900001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectPolymeric nanoparticlept_PT
dc.subjectSN-38pt_PT
dc.subjectSurfactant-drug interactionpt_PT
dc.titlePoly(l-lactide-co-caprolactone-co-glycolide)-based nanoparticles as delivery platform: effect of the surfactants on characteristics and delivery efficiencypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue9pt_PT
oaire.citation.titleNanomaterialspt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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