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The impact of metal ions on the photo-antibacterial efficiency of metalloporphyrins with triphenylphosphonium units

2025-08-01Artigo de investigação Acesso aberto
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dc.contributor.authorChaves, Inês
dc.contributor.authorMorais, Filipe F. M.
dc.contributor.authorVieira, Cátia
dc.contributor.authorBartolomeu, Maria
dc.contributor.authorGomes, Ana T. P. C.
dc.contributor.authorFaustino, M. Amparo F.
dc.contributor.authorNeves, M. Graça P. M. S.
dc.contributor.authorAlmeida, Adelaide
dc.contributor.authorMoura, Nuno M. M.
dc.date.accessioned2025-08-13T14:19:53Z
dc.date.available2025-08-13T14:19:53Z
dc.date.issued2025-08-01
dc.description.abstractThe influence of metal ions on the photochemical, photophysical, and antibacterial properties of three cationic porphyrin-triphenylphosphonium conjugates was investigated for the first time. Coordination with Zn(II), Pd(II) and Co(II) enabled fine-tuning of these conjugates properties, with Zn(II) complexes demonstrating particular promise. While Pd(II) and Co(II) complexes failed to generate singlet oxygen (1O2), thereby reducing their efficacy in bacteria photoinactivation, Zn(II) complexes exhibited efficient 1O2 generation and strong bacterial adhesion. Among these, the Zn(II) metalloporphyrin 2-Zn, featuring a well-optimized structure with three triphenylphosphonium units and six positive charges, showed exceptional effectiveness against Gram-negative Escherichia coli at lower concentrations. It significantly outperformed its free-base counterpart, reducing the required irradiation time by more than 65 %. Furthermore, 2-Zn demonstrates to be safe, exhibiting no cytotoxicity towards Vero cells. These findings highlight the potential of Zn(II) porphyrin-triphenylphosphonium complexes as efficient photosensitizers for antimicrobial photodynamic therapy (aPDT), offering a promising approach to address the growing challenge of antibiotic bacterial resistance in both clinical and environmental contexts.eng
dc.identifier.citationChaves, I., Morais, F. F. M., Vieira, C., & Bartolomeu, M. et al. (2025). The impact of metal ions on the photo-antibacterial efficiency of metalloporphyrins with triphenylphosphonium units. Inorganic Chemistry Communications, 178, Article 114426. https://doi.org/10.1016/j.inoche.2025.114426
dc.identifier.doi10.1016/j.inoche.2025.114426
dc.identifier.eid105001812580
dc.identifier.issn1387-7003
dc.identifier.other07adf899-a9f7-43e7-8f03-d0bf39aabee7
dc.identifier.urihttp://hdl.handle.net/10400.14/54543
dc.identifier.wos001465017600001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAntimicrobial photodynamic therapy
dc.subjectBacteria
dc.subjectMetalloporphyrin
dc.subjectPhotosensitizers
dc.subjectTriphenylphosphonium
dc.subjectZinc(II)
dc.titleThe impact of metal ions on the photo-antibacterial efficiency of metalloporphyrins with triphenylphosphonium unitseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleInorganic Chemistry Communications
oaire.citation.volume178
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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