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Naprt expression regulation mechanisms: novel functions predicted by a bioinformatics approach

2021-12Journal article Open access
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dc.contributor.authorDuarte-Pereira, Sara
dc.contributor.authorFajarda, Olga
dc.contributor.authorMatos, Sérgio
dc.contributor.authorOliveira, José Luís
dc.contributor.authorSilva, Raquel Monteiro
dc.date.accessioned2022-01-05T18:11:00Z
dc.date.available2022-01-05T18:11:00Z
dc.date.issued2021-12
dc.description.abstractThe nicotinate phosphoribosyltransferase (NAPRT) gene has gained relevance in the research of cancer therapeutic strategies due to its main role as a NAD biosynthetic enzyme. NAD metabolism is an attractive target for the development of anti-cancer therapies, given the high energy requirements of proliferating cancer cells and NAD-dependent signaling. A few studies have shown that NAPRT expression varies in different cancer types, making it imperative to assess NAPRT expression and functionality status prior to the application of therapeutic strategies targeting NAD. In addition, the recent finding of NAPRT extracellular form (eNAPRT) suggested the involvement of NAPRT in inflammation and signaling. However, the mechanisms regulating NAPRT gene expression have never been thoroughly addressed. In this study, we searched for NAPRT gene expression regulatory mechanisms in transcription factors (TFs), RNA binding proteins (RBPs) and microRNA (miRNAs) databases. We identified several potential regulators of NAPRT transcription activation, downregulation and alternative splicing and performed GO and expression analyses. The results of the functional analysis of TFs, RBPs and miRNAs suggest new, unexpected functions for the NAPRT gene in cell differentiation, development and neuronal biology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/genes12122022pt_PT
dc.identifier.eid85121650571
dc.identifier.issn2073-4425
dc.identifier.pmcPMC8700865
dc.identifier.pmid34946971
dc.identifier.urihttp://hdl.handle.net/10400.14/36362
dc.identifier.wos000737794700001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBioinformaticspt_PT
dc.subjectCell differentiationpt_PT
dc.subjectExpression regulationpt_PT
dc.subjectNAPRT (nicotinate phosphoribosyltransferase)pt_PT
dc.subjectNeurodevelopmentpt_PT
dc.titleNaprt expression regulation mechanisms: novel functions predicted by a bioinformatics approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue12pt_PT
oaire.citation.titleGenespt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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