Publication
Gene-environment interactions involving DNA repair SNPs and oral cancer risk : a systematic review
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | pt_PT |
| dc.contributor.advisor | Santos, Luís Filipe de Sepúlveda Silva | |
| dc.contributor.advisor | Silva, Raquel Monteiro Marques da | |
| dc.contributor.advisor | Couto, Patrícia Sofia Soares | |
| dc.contributor.author | Shimi, Jamila | |
| dc.date.accessioned | 2024-10-15T16:31:03Z | |
| dc.date.available | 2024-10-15T16:31:03Z | |
| dc.date.issued | 2024-07-31 | |
| dc.date.submitted | 2024 | |
| dc.description.abstract | Background and purpose: Oral cancer the sixth most predominant cancer worldwide. This systematic review aims to gather all prior evidence and establish an overall understanding about the possible interaction between DNA repair SNPs and environmental factors and the potential role that these interactions could have on oral cancer susceptibility. Method: Our systematic review was carried out through a comprehensive search in MEDLINE (via PubMed), Scopus, and Web of Science databases. Case-control studies examining interactions between DNA repair SNPs and environmental factors in oral cancer susceptibility were included with no year or language restrictions. This revision followed the PRISMA guidelines and was registered in Prospero (CRD42020143307). Rayyan and Excel were used for data extraction and analysis. Results: From the 422 GxE interactions that were investigated we observed 34 significant findings, confirming our hypothesis. NER and HR were the pathways most frequently involved in significant interactions. Smoking and, alcohol drinking were the main contributing environmental factors. NER pathway SNPs contributed mostly to interactions with smoking while HR pathway SNPs, were the major contributors to alcohol drinking interactions. ERCC2 rs13181 increased oral cancer risk in smokers (OR = 26.33, 95% CI = 7.87-88.04) and XRCC3 rs861539 interacted with different environmental factors to increase oral cancer risk. Conclusion: The NER and HR pathways interact with smoking or alcohol drinking to increase oral cancer risk. Interactions involving the ERCC2 rs13181 and XRCC3 rs861539 SNPs were the most consistent. Further studies in larger populations of different origins should be performed to confirm these findings. | pt_PT |
| dc.identifier.tid | 203706153 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.14/46981 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | Oral cancer | pt_PT |
| dc.subject | DNA repair | pt_PT |
| dc.subject | Single nucleotide polymorphisms (SNPs) | pt_PT |
| dc.subject | Interactions | pt_PT |
| dc.subject | Environmental agents | pt_PT |
| dc.subject | Oral cancer risk | pt_PT |
| dc.title | Gene-environment interactions involving DNA repair SNPs and oral cancer risk : a systematic review | pt_PT |
| dc.type | master thesis | |
| dspace.entity.type | Publication | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | masterThesis | pt_PT |
| thesis.degree.name | Mestrado em Medicina Dentária | pt_PT |