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Abstract(s)
Introdução - A Organização Mundial de Saúde define a obesidade infantil como uma prioridade de saúde pública e a sua prevenção desde os primeiros anos de vida e fundamental para a sua qualidade e longevidade. Para além do desequilíbrio alimentar e sedentarismo, também o ambiente intrauterino parece estar na génese do aparecimento desta patologia. O tecido adiposo tem um papel na regulação metabólica do organismo e esta regulação e feita através de adipocinas, como a leptina e a adiponectina. Estas adipocinas influenciam diretamente os processos metabólicos e endocrinos e a alteração das suas concentrações ao nascimento tem sido associada a obesidade na infância. Objetivos - O principal objetivo deste trabalho e avaliar a associação entre os níveis plasmáticos de leptina e adiponectina, no sangue do cordão umbilical e a adiposidade aos 4, 7 e 10 anos de idade em crianças da coorte de nascimentos portuguesa de base populacional, Geração XXI. Materiais e Métodos - A Geração XXI foi estabelecida ao nascimento, tendo sido reavaliada aos 4, 7 e 10 anos de idade. Neste estudo, foram incluídos 898 indivíduos com determinação de leptina e adiponectina, 895 com informação antropométrica aos 4 anos, 811 aos 7 anos e 750 aos 10 anos. A analise descritiva e analítica dos dados foi realizada com recurso ao programa Statistical Package for Social Sciences (SPSS) versão 27.0. Foi considerado um nível de significância de 5%. Resultados - Concentrações de leptina no tercil mais baixo (1oT) aumentam o risco de obesidade em raparigas aos 4 anos de idade, mesmo quando comparado com o risco associado aos que nasceram com concentrações de leptina no tercil mais elevado (3oT), 2,054 (IC 95%: 0,816; 5,167) vs. 1,570 (IC 95%: 0,665; 3,706). Também nas raparigas com 10 anos de idade se verificou um aumento do risco de obesidade perante níveis de leptina no tercil mais elevado: 2,258 (IC 95%: 1,063; 4,797) vs. 2,080 (IC 95% 0,890; 4,863). Relativamente aos rapazes, o risco de obesidade, aos 10 anos, foi superior perante concentrações de leptina no 3oT: 2,370 (IC 95%: 1,052; 5,340) vs. 2,175 (IC 95%: 1,041; 4,545). Aos 7 anos, não foram encontradas quaisquer associações entre leptina e obesidade. A adiponectina não se associou com nenhum dos parâmetros antropométricos avaliados, nas 3 faixas etárias, em ambos os sexos. Conclusão - Os resultados deste estudo corroboram a associação entre as concentrações de leptina ao nascimento e o risco de obesidade infantil, ate aos 10 anos. O mesmo não se observou relativamente a adiponectina.
Introduction - The World Health Organization defines childhood obesity as a public health priority and its prevention from the first years of life is important for its quality and longevity. In addition to dietary imbalance and sedentary lifestyle, the intrauterine environment also seems to be at the genesis of the onset of this pathology. Adipose tissue plays a role in metabolic regulation and this regulation is done through adipokines such as leptin and adiponectin. These adipokines directly influence metabolic and endocrine processes and their changings at birth has been linked to childhood obesity. Aims - The main objective of this work is to evaluate the association between plasma levels of leptin and adiponectin in umbilical cord blood and adiposity at 4, 7 and 10 years of age in children from the Portuguese populationbased birth cohort, Geração XXI. Materials and methods – Generation XXI was established at birth, having been re-evaluated at 4, 7 and 10 years of age. In this study, 898 individuals with determination of leptin and adiponectin were included, 895 with anthropometric information at 4 years, 811 at 7 years and 750 at 10 years. Descriptive and analytical data analysis was performed using the Statistical Package for Social Sciences (SPSS) version 27.0. A significance level of 5% was considered. Results - Leptin concentrations in the lowest tertile (1stT) increase the risk of obesity in 4-year-old girls, even when compared with the risk associated with those born with leptin concentrations in the highest tertile (3rdT), 2.054 (95% CI): 0.816; 5.167) vs. 1.570 (95% CI: 0.665; 3.706). Also, in 10-year-old girls there was an increased risk of obesity in the presence of leptin levels in the highest tertile: 2.258 (95% CI: 1.063; 4.797) vs. 2.080 (95% CI 0.890; 4.863). Regarding boys, the risk of obesity, at 10 years of age, was higher when compared to leptin concentrations in the 3rd T: 2.370 (95% CI: 1.052; 5.340) vs. 2.175 (95% CI: 1.041; 4.545). At 7 years, no associations were found between leptin and obesity. Adiponectin was not associated with any of the anthropometric parameters evaluated, in the 3 age groups, in both sexes. Conclusion- The results of this study support the association between leptin concentrations at birth and the risk of childhood obesity, up to 10 years of age. The same was not observed for adiponectin
Introduction - The World Health Organization defines childhood obesity as a public health priority and its prevention from the first years of life is important for its quality and longevity. In addition to dietary imbalance and sedentary lifestyle, the intrauterine environment also seems to be at the genesis of the onset of this pathology. Adipose tissue plays a role in metabolic regulation and this regulation is done through adipokines such as leptin and adiponectin. These adipokines directly influence metabolic and endocrine processes and their changings at birth has been linked to childhood obesity. Aims - The main objective of this work is to evaluate the association between plasma levels of leptin and adiponectin in umbilical cord blood and adiposity at 4, 7 and 10 years of age in children from the Portuguese populationbased birth cohort, Geração XXI. Materials and methods – Generation XXI was established at birth, having been re-evaluated at 4, 7 and 10 years of age. In this study, 898 individuals with determination of leptin and adiponectin were included, 895 with anthropometric information at 4 years, 811 at 7 years and 750 at 10 years. Descriptive and analytical data analysis was performed using the Statistical Package for Social Sciences (SPSS) version 27.0. A significance level of 5% was considered. Results - Leptin concentrations in the lowest tertile (1stT) increase the risk of obesity in 4-year-old girls, even when compared with the risk associated with those born with leptin concentrations in the highest tertile (3rdT), 2.054 (95% CI): 0.816; 5.167) vs. 1.570 (95% CI: 0.665; 3.706). Also, in 10-year-old girls there was an increased risk of obesity in the presence of leptin levels in the highest tertile: 2.258 (95% CI: 1.063; 4.797) vs. 2.080 (95% CI 0.890; 4.863). Regarding boys, the risk of obesity, at 10 years of age, was higher when compared to leptin concentrations in the 3rd T: 2.370 (95% CI: 1.052; 5.340) vs. 2.175 (95% CI: 1.041; 4.545). At 7 years, no associations were found between leptin and obesity. Adiponectin was not associated with any of the anthropometric parameters evaluated, in the 3 age groups, in both sexes. Conclusion- The results of this study support the association between leptin concentrations at birth and the risk of childhood obesity, up to 10 years of age. The same was not observed for adiponectin
Description
Keywords
Obesidade infantil Gestação Leptina Adiponectina Childhood obesity Pregnancy Leptin Adiponectin