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Long COVID as a risk factor for hypersomnolence and fatigue: insights from the 2nd International Covid Sleep Study Collaboration (ICOSS-2)

2025-12-01Artigo de investigação Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorSarkanen, Tomi
dc.contributor.authorMerikanto, Ilona
dc.contributor.authorBjorvatn, Bjorn
dc.contributor.authorChung, Frances
dc.contributor.authorHolzinger, Brigitte
dc.contributor.authorMorin, Charles M.
dc.contributor.authorPenzel, Thomas
dc.contributor.authorGennaro, Luigi de
dc.contributor.authorWing, Yun Kwok
dc.contributor.authorBenedict, Christian
dc.contributor.authorXue, Pei
dc.contributor.authorReis, Cátia
dc.contributor.authorKorman, Maria
dc.contributor.authorLandtblom, Anne-Marie
dc.contributor.authorMatsui, Kentaro
dc.contributor.authorHrubos-Strom, Harald
dc.contributor.authorMota-Rolim, Sergio
dc.contributor.authorNadorff, Michael R.
dc.contributor.authorBerezin, Linor
dc.contributor.authorLiu, Yaping
dc.contributor.authorScarpelli, Serena
dc.contributor.authorBrandão, Luiz E. M.
dc.contributor.authorCedernaes, Jonathan
dc.contributor.authorPartinen, Eemil
dc.contributor.authorBolstad, Courtney J.
dc.contributor.authorPlazzi, Giuseppe
dc.contributor.authorEspie, Colin A.
dc.contributor.authorPartinen, Markku
dc.contributor.authorDauvilliers, Yves
dc.date.accessioned2025-11-19T07:49:41Z
dc.date.available2025-11-19T07:49:41Z
dc.date.issued2025-12-01
dc.description.abstractBackground: Hypersomnolence, defined as excessive daytime sleepiness (EDS), excessive quantity of sleep (EQS), sleep inertia, and fatigue reduce quality of life. We assessed associations of the COVID-19 pandemic, infection without long-term sequalae (short COVID, SC), and long COVID (LC) on hypersomnolence and fatigue in a large population across different countries. Methods: As part of an online questionnaire (ICOSS-2), we assessed EDS via the Epworth Sleepiness Scale (ESS), fatigue via Fatigue Severity Scale (FSS), and sleep duration at night and per 24 h. We also assessed the associations with EDS, sleep inertia, fatigue and napping by their frequencies, during the pandemic in COVID-negative, SC and LC participants. Results: The final cohort comprised 13,656 participants (69.1 % women, 42.7 ± 16.6 years), with 12.4 % classified SC and 7.5 % LC. ESS scores were higher in LC (9.16, 95 % CI [8.78, 9.53]) compared to SC (7.26, [6.97, 7.55]) and COVID-negative (6.53, [6.43, 6.63]). LC also had higher odds of ESS>10 (OR 1.58, [1.18,2.09]). FSS scores were higher in LC (median 51, IQR 39–59) than SC (34, 25–44) and COVID-negative (35, 25–45), with LC having 2.22 higher odds of severe fatigue. LC cases also reported more EQS (?10/24 h) than COVID-negative. Worsening of EDS, fatigue, sleep inertia, and napping was reported during pandemic to a greater extent in LC. Conclusions: LC was associated with higher levels of hypersomnolence and fatigue than in SC or COVID-negative participants, highlighting the need for interventions and future research focusing on sleep symptoms and their relation to long-term health outcomes.eng
dc.identifier.citationSarkanen, T., Merikanto, I., Bjorvatn, B., & Chung, F. et al. (2025). Long COVID as a risk factor for hypersomnolence and fatigue: insights from the 2nd International Covid Sleep Study Collaboration (ICOSS-2). Sleep Medicine, 136, Article 106764. https://doi.org/10.1016/j.sleep.2025.106764
dc.identifier.doi10.1016/j.sleep.2025.106764
dc.identifier.issn1389-9457
dc.identifier.other2137eec1-0a9a-4347-ad8b-935d8b4fd2e1
dc.identifier.pmid41124977
dc.identifier.urihttp://hdl.handle.net/10400.14/55684
dc.identifier.wos001606305900003
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFatigue
dc.subjectHypersomnolence
dc.subjectLong COVID
dc.subjectSleep inertia
dc.subjectSleepiness
dc.titleLong COVID as a risk factor for hypersomnolence and fatigue: insights from the 2nd International Covid Sleep Study Collaboration (ICOSS-2)eng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleSleep Medicine
oaire.citation.volume136
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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