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Abstract(s)
A Diabetes Melitos é uma doença de grande prevalência a nível
mundial e os seus mecanismos fisiopatológicos não são ainda totalmente
conhecidos.
Actualmente, a terapêutica seguida em casos de Diabetes Melitos é
eminentemente sintomática consistindo na administração de insulina nos
casos de Diabetes Melitos tipo 1 ou quando se verifica a falência das células
beta do pâncreas de pacientes com Diabetes Melitos tipo 2, ou no controlo da
glicemia nos casos de Diabetes Melitos tipo 2.
A hiperglicemia, fenótipo característico desta patologia, produz efeitos
negativos no organismo a longo prazo, levando à modificação estrutural e
funcional de vários proteínas, afectando, deste modo, diversos processos
moleculares em que intervêm estas proteínas.
Os dois tipos Diabetes Melitos influenciam, de forma diferenciada, a
expressão de diversas proteínas, produzindo efeitos ao nível das vias de
sinalização celular e nos processos biológicos celulares.
Consequentemente, conhecer as características moleculares dos dois
tipos de Diabetes Melitos permite o desenvolvimento de técnicas diagnósticas
e terapêuticas mais precoces e eficazes específicas para cada uma delas.
Tendo como base o proteoma da cavidade oral, denominado Oraloma,
este estudo pretende actualizar os dados provenientes de estudos de
proteómica da cavidade oral de pacientes com os dois tipos de Diabetes
Melitos e estudá-los com recurso a ferramentas bioinformáticas que permitem
a caracterização das proteínas indexadas.
Dado a cavidade oral ser um ecossistema, é indissociável dos
microrganismos que nele existem. Consequentemente, é objectivo deste
estudo anotar as estirpes de microrganismos identificados pela literatura
actual, por forma a caracterizar de forma mais completa este aspecto
molecular da cavidade oral
Diabetes Mellitos is a disease with high prevalence worldwide with pathophysiological mechanisms not yet fully understood. Nowadays, the therapeutical approach of Diabetes Mellitos is mainly a symptomatic one based on insulin administration to type 1 Diabetes Mellitus patients and type 2 Diabetes Mellitus patients with no funtional pancreatic beta-cells or the serum glucose concentration control in type 2 Diabetes Mellitus patients. Hyperglykemia is a carachteristic phenotype of this pathology, it brings long-run negative effects on the organism due to its role on modifying proteins structure and function affecting the organism's integrity. Both Diabetes Mellitus types influence, on different ways, protein expression hence leading to changes on the molecular signaling pathways and biologic process of the cells. Thereafter, to know the molecular aspects of both Diabetes Mellitus types is key to develop better, more efficient and precocious diagnostic and therapeutic tecniques. Based on the oral proteome, namely the oralome, this study aims to update data from the pre-existing oral proteomic studies on both types of Diabetes Mellitus and to study them using bioinformatic tools which allow these proteins carachterization. Being an ecossystem, the oral cavity is inseparable of the microrganisms which inhabit in it. Therefore, another aim of the present study is to annotate the microrganisms species identified by the current scientific literature, in order to charactherize in a more complete way this molecular aspect of the oral cavity.
Diabetes Mellitos is a disease with high prevalence worldwide with pathophysiological mechanisms not yet fully understood. Nowadays, the therapeutical approach of Diabetes Mellitos is mainly a symptomatic one based on insulin administration to type 1 Diabetes Mellitus patients and type 2 Diabetes Mellitus patients with no funtional pancreatic beta-cells or the serum glucose concentration control in type 2 Diabetes Mellitus patients. Hyperglykemia is a carachteristic phenotype of this pathology, it brings long-run negative effects on the organism due to its role on modifying proteins structure and function affecting the organism's integrity. Both Diabetes Mellitus types influence, on different ways, protein expression hence leading to changes on the molecular signaling pathways and biologic process of the cells. Thereafter, to know the molecular aspects of both Diabetes Mellitus types is key to develop better, more efficient and precocious diagnostic and therapeutic tecniques. Based on the oral proteome, namely the oralome, this study aims to update data from the pre-existing oral proteomic studies on both types of Diabetes Mellitus and to study them using bioinformatic tools which allow these proteins carachterization. Being an ecossystem, the oral cavity is inseparable of the microrganisms which inhabit in it. Therefore, another aim of the present study is to annotate the microrganisms species identified by the current scientific literature, in order to charactherize in a more complete way this molecular aspect of the oral cavity.
Description
Keywords
Diabetes Oraloma Proteómica Bioinformática Diabetes Oralome Proteomics Bioinformatics