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Unravelling the triad of neuroinvasion, neurodissemination, and neuroinflammation of human immunodeficiency virus type 1 in the central nervous system

2024-05Journal article Open access
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dc.contributor.authorCalado, Marta
dc.contributor.authorFerreira, Rita
dc.contributor.authorPires, David
dc.contributor.authorSantos-Costa, Quirina
dc.contributor.authorAnes, Elsa
dc.contributor.authorBrites, Dora
dc.contributor.authorAzevedo-Pereira, José Miguel
dc.date.accessioned2024-04-17T12:23:46Z
dc.date.available2024-04-17T12:23:46Z
dc.date.issued2024-05
dc.description.abstractSince the identification of human immunodeficiency virus type 1 (HIV-1) in 1983, many improvements have been made to control viral replication in the peripheral blood and to treat opportunistic infections. This has increased life expectancy but also the incidence of age-related central nervous system (CNS) disorders and HIV-associated neurodegeneration/neurocognitive impairment and depression collectively referred to as HIV-associated neurocognitive disorders (HAND). HAND encompasses a spectrum of different clinical presentations ranging from milder forms such as asymptomatic neurocognitive impairment or mild neurocognitive disorder to a severe HIV-associated dementia (HAD). Although control of viral replication and suppression of plasma viral load with combination antiretroviral therapy has reduced the incidence of HAD, it has not reversed milder forms of HAND. The objective of this review, is to describe the mechanisms by which HIV-1 invades and disseminates in the CNS, a crucial event leading to HAND. The review will present the evidence that underlies the relationship between HIV infection and HAND. Additionally, recent findings explaining the role of neuroinflammation in the pathogenesis of HAND will be discussed, along with prospects for treatment and control.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/rmv.2534pt_PT
dc.identifier.eid85189613833
dc.identifier.issn1052-9276
dc.identifier.pmid38588024
dc.identifier.urihttp://hdl.handle.net/10400.14/44654
dc.identifier.wos001198223400001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCentral nervous systempt_PT
dc.subjectHIV-1pt_PT
dc.subjectHIV-associated neurocognitive disorderspt_PT
dc.subjectHIV-cell interactionspt_PT
dc.titleUnravelling the triad of neuroinvasion, neurodissemination, and neuroinflammation of human immunodeficiency virus type 1 in the central nervous systempt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.titleReviews in Medical Virologypt_PT
oaire.citation.volume34pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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