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Ethical and scientific pitfalls concerning laboratory research with non-human primates, and possible solutions

2019-01-01Journal article Open access
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dc.contributor.authorCarvalho, Constança
dc.contributor.authorGaspar, Augusta
dc.contributor.authorKnight, Andrew
dc.contributor.authorVicente, Luís
dc.date.accessioned2021-04-13T09:40:40Z
dc.date.available2021-04-13T09:40:40Z
dc.date.issued2019-01-01
dc.description.abstractBasic and applied laboratory research, whenever intrusive or invasive, presents substantial ethical challenges for ethical committees, be it with human beings or with non-human animals. In this paper we discuss the use of non-human primates (NHPs), mostly as animal models, in laboratory based research. We examine the two ethical frameworks that support current legislation and guidelines: deontology and utilitarianism. While human based research is regulated under deontological principles, guidelines for laboratory animal research rely on utilitarianism. We argue that the utilitarian framework is inadequate for this purpose: on the one hand, it is almost impossible to accurately predict the benefits of a study for all potential stakeholders; and on the other hand, harm inflicted on NHPs (and other animals) used in laboratory research is extensive despite the increasing efforts of ethics committees and the research community to address this. Although deontology and utilitarianism are both valid ethical frameworks, we advocate that a deontological approach is more suitable, since we arguably have moral duties to NHPs. We provide suggestions on how to ensure that research currently conducted in laboratory settings shifts towards approaches that abide by deontological principles. We assert that this would not impede reasonable scientific research.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ani9010012pt_PT
dc.identifier.eid85060039950
dc.identifier.issn2076-2615
dc.identifier.urihttp://hdl.handle.net/10400.14/32517
dc.identifier.wos000459727300012
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimal use alternativespt_PT
dc.subjectBiomedical researchpt_PT
dc.subjectDeontologypt_PT
dc.subjectNon-human primate researchpt_PT
dc.subjectUtilitarianismpt_PT
dc.titleEthical and scientific pitfalls concerning laboratory research with non-human primates, and possible solutionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleAnimalspt_PT
oaire.citation.volume9pt_PT
person.familyNameCarvalho
person.familyNameDuarte Gaspar
person.familyNameKnight
person.familyNameVicente
person.givenNameConstança
person.givenNameMaria Augusta
person.givenNameAndrew
person.givenNameLuis
person.identifier1011526
person.identifier.ciencia-id2815-B57D-7121
person.identifier.ciencia-id5211-6069-7EA1
person.identifier.orcid0000-0002-6902-4241
person.identifier.orcid0000-0001-9758-5727
person.identifier.orcid0000-0002-9753-6199
person.identifier.orcid0000-0002-3383-5480
person.identifier.ridAAA-3707-2020
person.identifier.ridA-7443-2013
person.identifier.scopus-author-id14045057300
person.identifier.scopus-author-id7202814962
person.identifier.scopus-author-id7006690298
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery1a8fffaa-b3f0-40f8-83ce-d49e1ed4bfb3

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