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Evaluation and insights into chitosan antimicrobial activity against anaerobic oral pathogens

2012Journal article Restricted access
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dc.contributor.authorCosta, E.M.
dc.contributor.authorSilva, S.
dc.contributor.authorPina, C.
dc.contributor.authorTavaria, F.K.
dc.contributor.authorPintado, M.M.
dc.date.accessioned2013-01-28T11:09:19Z
dc.date.available2013-01-28T11:09:19Z
dc.date.issued2012
dc.description.abstractThe objective of this study was to assess the antimicrobial capability of non-chemically altered chitosan as an alternative to traditional antimicrobials used in the treatment of oral infections. The action mechanism of chitosan was also ascertained. High and low molecular weight chitosan showed antimicrobial activity at low concentrations for all tested bacteria with the MICs varying between 1 and 7 mg/ ml with a drop of efficacy relatively to the action of LMW chitosan. In addition chitosan showed also to be an effective bactericidal presenting bactericidal effect within 8 h at the latest. Additionally the evaluation of chitosan’s action mechanism showed that both MWs acted upon the bacterial cell wall and were not capable of interacting with the intracellular substances, as showed by the inefficacy obtained in the flocculation assaypor
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationCOSTA, E. M... [et al.] - Evaluation and insights into chitosan antimicrobial activity against anaerobic oral pathogens. Anaerobe. ISSN 1075-9964. Vol. 18, n.º 3 (2012), p. 305-309por
dc.identifier.doi10.1016/j.anaerobe.2012.04.009
dc.identifier.eissn1095-8274
dc.identifier.issn1075-9964
dc.identifier.urihttp://hdl.handle.net/10400.14/9967
dc.identifier.wosWOS:000305855600009
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationQREN-ADI 3474
dc.subjectAnaerobic pathogenspor
dc.subjectAntimicrobialpor
dc.subjectChitosanpor
dc.subjectAction mechanismpor
dc.titleEvaluation and insights into chitosan antimicrobial activity against anaerobic oral pathogenspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage309
oaire.citation.issue3
oaire.citation.startPage305
oaire.citation.titleAnaerobe
oaire.citation.volume18
person.familyNameCosta
person.familyNameSilva
person.familyNamePina
person.familyNameKekhasharú Tavaria
person.familyNamePintado
person.givenNameEduardo
person.givenNameSara
person.givenNameCristina
person.givenNameFreni
person.givenNameMaria Manuela
person.identifier1888852
person.identifier456608
person.identifier.ciencia-idB218-870B-98B5
person.identifier.ciencia-id8E18-0AFF-BF6D
person.identifier.ciencia-id5D11-7378-444A
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0001-8268-2137
person.identifier.orcid0000-0002-3880-4712
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55249865700
person.identifier.scopus-author-id55158300800
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id7004483898
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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