Orientador(es)
Resumo(s)
The objective of this study was to assess the antimicrobial capability of non-chemically altered chitosan
as an alternative to traditional antimicrobials used in the treatment of oral infections. The action
mechanism of chitosan was also ascertained. High and low molecular weight chitosan showed antimicrobial
activity at low concentrations for all tested bacteria with the MICs varying between 1 and 7 mg/
ml with a drop of efficacy relatively to the action of LMW chitosan. In addition chitosan showed also to be
an effective bactericidal presenting bactericidal effect within 8 h at the latest. Additionally the evaluation
of chitosan’s action mechanism showed that both MWs acted upon the bacterial cell wall and were not
capable of interacting with the intracellular substances, as showed by the inefficacy obtained in the
flocculation assay
Descrição
Palavras-chave
Anaerobic pathogens Antimicrobial Chitosan Action mechanism
Contexto Educativo
Citação
COSTA, E. M... [et al.] - Evaluation and insights into chitosan antimicrobial activity against anaerobic oral pathogens. Anaerobe. ISSN 1075-9964. Vol. 18, n.º 3 (2012), p. 305-309
Editora
Elsevier