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Update on the role of antiseptics in the management of chronic wounds with critical colonisation and/or biofilm

2021-06-01Journal article Open access
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dc.contributor.authorAlves, Paulo J.
dc.contributor.authorBarreto, Ruben T.
dc.contributor.authorBarrois, Brigitte M.
dc.contributor.authorGryson, Luc G.
dc.contributor.authorMeaume, Sylvie
dc.contributor.authorMonstrey, Stan J.
dc.date.accessioned2021-01-06T18:15:26Z
dc.date.available2021-01-06T18:15:26Z
dc.date.issued2021-06-01
dc.description.abstractBiofilms play a major role in delaying chronic wounds from healing. A wound infiltrated with biofilm, or “critically colonised” wound, may become clinically infected if the number of microbes exceeds a critical level. Chronic wound biofilms represent a significant treatment challenge by demonstrating recalcitrance towards antimicrobial agents. However, a “window of opportunity” may exist after wound debridement when biofilms are more susceptible to topical antiseptics. Here, we discuss the role of antiseptics in the management of chronic wounds and biofilm, focusing on povidone-iodine (PVP-I) in comparison with two commonly used antiseptics: polyhexanide (PHMB) and silver. This article is based on the literature reviewed during a focus group meeting on antiseptics in wound care and biofilm management, and on a PubMed search conducted in March 2020. Compared with PHMB and silver, PVP-I has a broader spectrum of antimicrobial activity, potent antibiofilm efficacy, no acquired bacterial resistance or cross-resistance, low cytotoxicity, good tolerability, and an ability to promote wound healing. PVP-I represents a viable therapeutic option in wound care and biofilm management, with the potential to treat biofilm-infiltrated, critically colonised wounds. We propose a practical algorithm to guide the management of chronic, non-healing wounds due to critical colonisation or biofilm, using PVP-I.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves, P. J., Barreto, R. T., Barrois, B. M., Gryson, L. G., Meaume, S., & Monstrey, S. J. (2021). Update on the role of antiseptics in the management of chronic wounds with critical colonisation and/or biofilm. International Wound Journal, 18(3), 342-358. https://doi.org/10.1111/iwj.13537pt_PT
dc.identifier.doi10.1111/iwj.13537pt_PT
dc.identifier.eid85097490413
dc.identifier.pmcPMC8244012
dc.identifier.pmid33314723
dc.identifier.urihttp://hdl.handle.net/10400.14/31590
dc.identifier.wos000598322800001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiguanidept_PT
dc.subjectBiofilmspt_PT
dc.subjectPovidone-iodinept_PT
dc.subjectSilverpt_PT
dc.subjectWound healingpt_PT
dc.titleUpdate on the role of antiseptics in the management of chronic wounds with critical colonisation and/or biofilmpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage358
oaire.citation.issue3
oaire.citation.startPage342
oaire.citation.titleInternational Wound Journalpt_PT
oaire.citation.volume18
person.familyNameAlves
person.givenNamePaulo
person.identifier.ciencia-id8C12-EBAE-B385
person.identifier.orcid0000-0002-9421-854X
person.identifier.scopus-author-id55206239400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9d156779-61a9-4249-b112-5832c42094f4
relation.isAuthorOfPublication.latestForDiscovery9d156779-61a9-4249-b112-5832c42094f4

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