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Therapeutic and nutraceutical potential of rosmarinic acid-Cytoprotective properties and pharmacokinetic profile

2017Journal article Restricted access
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dc.contributor.authorNunes, Sara
dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorCampos, Débora
dc.contributor.authorSarmento, Bruno
dc.contributor.authorGomes, Ana Maria
dc.contributor.authorPintado, Manuela
dc.contributor.authorReis, Flávio
dc.date.accessioned2017-10-17T13:48:36Z
dc.date.available2017-10-17T13:48:36Z
dc.date.issued2017
dc.description.abstractRosmarinic acid (RA) is a natural polyphenolic antioxidant derived from many common herbal plants. This compound displays several important biological properties, including anti-inflammatory, antiviral, antibacterial, antidepressant, anticarcionogenic, and chemopreventive properties. The importance of its activities and its possible application in processed foods as a natural antioxidant has reached a new interest levels in recent years. The health effects of this polyphenol depend greatly on both its intakes and bioavailability. This review focuses on the importance of RA as a dietary supplement, and summarizes its pharmacokinetics and metabolism, including the factors that limit its oral bioavailability which leads to a lower therapeutic action. Further experimental investigations are needed to optimize and enhance the oral bioavailability of this natural compound which consequently will help increasing therapeutic efficacy of RA in vivo.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNUNES, Sara; MADUREIRA, Ana Raquel; CAMPOS, Débora A.; SARMENTO, Bruno; GOMES, Ana M. P.; PINTADO, M. E.; Reis, Flávio - Therapeutic and nutraceutical potential of rosmarinic acid-Cytoprotective properties and pharmacokinetic profile. Critical Reviews in Food Science and Nutrition. ISSN 1549-7852. Vol. 57, n.º 9 (2017), p. 1799-1806pt_PT
dc.identifier.doi10.1080/10408398.2015.1006768pt_PT
dc.identifier.eid85014885468
dc.identifier.eissn1549-7852
dc.identifier.issn1040-8398
dc.identifier.pmid26114303
dc.identifier.urihttp://hdl.handle.net/10400.14/23150
dc.identifier.wos000396781200004
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francis
dc.relationFCOMP-01-0124-FEDER-028417pt_PT
dc.relationPOCI-01-0145-FEDER-007440pt_PT
dc.relationCrosstalk between gut microbiota and metabolic dysregulation in prediabetes – Impact of nutraceutical and therapeutic approaches
dc.subjectRosmarinic acidpt_PT
dc.subjectTherapeuticpt_PT
dc.subjectNutraceuticalpt_PT
dc.subjectCytoprotective propertiespt_PT
dc.subjectPharmacokinetic profilept_PT
dc.subjectIn vivo modelspt_PT
dc.titleTherapeutic and nutraceutical potential of rosmarinic acid-Cytoprotective properties and pharmacokinetic profilept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCrosstalk between gut microbiota and metabolic dysregulation in prediabetes – Impact of nutraceutical and therapeutic approaches
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-ALI%2F117808%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0016%2F2013/PT
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oaire.citation.endPage1806
oaire.citation.issue9
oaire.citation.startPage1799
oaire.citation.titleCritical Reviews in Food Science and Nutritionpt_PT
oaire.citation.volume57
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person.familyNameNunes
person.familyNameMadureira
person.familyNameCampos
person.familyNameSarmento
person.familyNameGomes
person.familyNamePintado
person.familyNameReis
person.givenNameSara Raquel
person.givenNameRaquel
person.givenNameDébora
person.givenNameBruno
person.givenNameAna Maria
person.givenNameMaria Manuela
person.givenNameFlávio
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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