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Authors
Nunes, Sara
Madureira, Ana Raquel
Campos, Débora
Sarmento, Bruno
Advisor(s)
Abstract(s)
Rosmarinic acid (RA) is a natural polyphenolic antioxidant derived from many common herbal plants. This compound displays several important biological properties, including anti-inflammatory, antiviral, antibacterial, antidepressant, anticarcionogenic, and chemopreventive properties. The importance of its activities and its possible application in processed foods as a natural antioxidant has reached a new interest levels in recent years. The health effects of this polyphenol depend greatly on both its intakes and bioavailability. This review focuses on the importance of RA as a dietary supplement, and summarizes its pharmacokinetics and metabolism, including the factors that limit its oral bioavailability which leads to a lower therapeutic action. Further experimental investigations are needed to optimize and enhance the oral bioavailability of this natural compound which consequently will help increasing therapeutic efficacy of RA in vivo.
Description
Keywords
Rosmarinic acid Therapeutic Nutraceutical Cytoprotective properties Pharmacokinetic profile In vivo models
Pedagogical Context
Citation
NUNES, Sara; MADUREIRA, Ana Raquel; CAMPOS, Débora A.; SARMENTO, Bruno; GOMES, Ana M. P.; PINTADO, M. E.; Reis, Flávio - Therapeutic and nutraceutical potential of rosmarinic acid-Cytoprotective properties and pharmacokinetic profile. Critical Reviews in Food Science and Nutrition. ISSN 1549-7852. Vol. 57, n.º 9 (2017), p. 1799-1806
Publisher
Taylor & Francis