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Antimicrobial potential of bioactive resin composites in caries management: a systematic review of in vitro studies

2025-10-28Artigo de revisão Acesso aberto
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dc.contributor.authorLopes, Sara
dc.contributor.authorLopes, Pedro C.
dc.contributor.authorFidalgo-Pereira, Rita
dc.contributor.authorFlores-Fraile, Javier
dc.contributor.authorVeiga, Nélio
dc.contributor.authorGomes, Ana T. P. C.
dc.date.accessioned2025-12-02T12:46:10Z
dc.date.available2025-12-02T12:46:10Z
dc.date.issued2025-10-28
dc.description.abstractIntroduction: Secondary caries is the leading cause of failure in resin composite restorations due to biofilm accumulation. Bioactive resin composites (BRCs) release ions that promote remineralization and inhibit bacterial growth. This review compares microbial adhesion and antimicrobial effectiveness between BRCs and conventional resin composites. Methods: A systematic search was conducted in databases PubMed, Scopus, and Cochrane Library to identify in vitro studies evaluating bacterial adhesion and antimicrobial effect of commercially available bioactive resin composites and their comparison with conventional resin composites. Studies reporting on microbial adhesion and/or antimicrobial effects were included. Results: A total of 272 potentially relevant articles were identified. Following PRISMA guidelines, eight articles met the inclusion criteria. The studies focused on five commercially available BRCs: Activa Bioactive Restorative (ACT), Beautifil II (BE), Cention N (CN), Equia Forte (EF), and SDR Flow Plus. Most studies assessed the adhesion of Streptococcus mutans in isolation. While microbial adhesion was observed on both bioactive and conventional resin composites, cell viability differed, with BRCs demonstrating superior antimicrobial effects. Conclusion: Bacterial adhesion to dental restorative materials is influenced by surface roughness, hydrophilicity, chemical composition, and ion release. This review suggests that BRCs and conventional resin composites exhibit similar surface characteristics, resulting in comparable bacterial adhesion. However, BRCs show greater efficacy in reducing bacterial viability, probably due to ion release, which modulates the local microenvironment and microbial dynamics. Further research is needed to explore the broader impact of ion release on the oral microbiome and its potential role in dysbiosis and disease progression.eng
dc.identifier.citationLopes, S., Lopes, P. C., Fidalgo-Pereira, R., & Flores-Fraile, J. et al. (2025). Antimicrobial potential of bioactive resin composites in caries management: a systematic review of in vitro studies. Frontiers in Oral Health, 6, Article 1625977. https://doi.org/10.3389/froh.2025.1625977
dc.identifier.doi10.3389/froh.2025.1625977
dc.identifier.eid105021549368
dc.identifier.other2580cedc-a057-40db-b42f-bce10a0510d7
dc.identifier.pmcPMC12602406
dc.identifier.pmid41230539
dc.identifier.urihttp://hdl.handle.net/10400.14/55804
dc.identifier.wos001613641000001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBioactive resin composites
dc.subjectMicroorganism adhesion
dc.subjectResin composites
dc.subjectSecondary caries
dc.subjectSurface roughness
dc.titleAntimicrobial potential of bioactive resin composites in caries management: a systematic review of in vitro studieseng
dc.typereview article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Oral Health
oaire.citation.volume6
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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