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Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review

2022-02-17Journal article Open access
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dc.contributor.authorTavares, Lisandra Taísa Reginaldo
dc.contributor.authorSaavedra-Silva, Mariana
dc.contributor.authorLópez-Marcos, Joaquín Francisco
dc.contributor.authorVeiga, Nélio Jorge
dc.contributor.authorCastilho, Rogerio de Moraes
dc.contributor.authorFernandes, Gustavo Vicentis de Oliveira
dc.date.accessioned2022-03-30T16:09:18Z
dc.date.available2022-03-30T16:09:18Z
dc.date.issued2022-02-17
dc.description.abstractIntroduction: Periodontitis is the most prevalent inflammatory disease worldwide. Its inflammatory levels spread systemically, which can be associated with chronic kidney disease. Biomarkers have the potential to diagnose and correlate periodontitis and chronic kidney disease, helping to monitor systemic inflammation. Thereby, this study aimed to analyze the association between chronic kidney disease and periodontitis by conducting a biomarker analysis on blood and saliva. Material and methods: An electronic search through PubMed/MEDLINE, EMBASE, and Web of Science databases was conducted to identify clinical studies published in the last ten years, with no language restrictions. Twelve articles met all the inclusion criteria, two randomized controlled trials, one cohort study, and nine observational studies. Results: The studies included a total of 117 patients for saliva biomarkers, with a mean age of approximately 57 years old, and 56.68% of the subjects were female. After analyzing all the included studies, it was possible to verify the following biomarkers assessed: CRP, WBC, fibrinogen, IL-4 and -6, cardiac troponin T, NOx, ADMA, albumin, osteocalcin, cystatin C, PGLYRP1, cholesterol, HDL, LDL, triglycerides, and hemoglobin. Conclusion: A direct cause–effect association between periodontitis and CKD could not be established. However, it was possible to conclude that there was a correlating effect present, through the analyzed biomarkers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/diseases10010012pt_PT
dc.identifier.eid85142492700
dc.identifier.issn2079-9721
dc.identifier.pmcPMC8883939
dc.identifier.pmid35225864
dc.identifier.urihttp://hdl.handle.net/10400.14/37201
dc.identifier.wos000775432100001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiomarkerspt_PT
dc.subjectChronic kidney diseasept_PT
dc.subjectPeriodontitispt_PT
dc.subjectProteinspt_PT
dc.subjectSystematic reviewpt_PT
dc.titleBlood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleDiseasespt_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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