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Dairy products: is there an impact on promotion of prostate cancer? A review of the literature

2019-05-14Journal article Open access
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dc.contributor.authorVasconcelos, Alexandra
dc.contributor.authorSantos, Teresa
dc.contributor.authorRavasco, Paula
dc.contributor.authorNeves, Pedro Miguel
dc.date.accessioned2021-03-31T15:27:38Z
dc.date.available2021-03-31T15:27:38Z
dc.date.issued2019-05-14
dc.description.abstractThis review of the literature aims to study potential associations between high consumption of milk and/or dairy products and prostate cancer (PC). Literature is scarce, yet there is a direct relationship between mTORC1 activation and PC; several ingredients in milk/dairy products, when in high concentrations, increase signaling of the mTORC1 pathway. However, there are no studies showing an unequivocal relationship between milk products PC initiation and/or progression. Three different reviews were conducted with articles published in the last 5 years: (M1) PC and intake of dairy products, taking into account the possible mTORC1signaling mechanism; (M2) Intake of milk products and incidence/promotion of PC; (M3) mTORC1 activation signaling pathway, levels of IGF-1 and PC; (M4) mTORC pathway and dairy products. Of the 32 reviews identified, only 21 met the inclusion criteria and were analyzed. There is little scientific evidence that directly link the three factors: incidence/promotion of PC, intake of dairy products and PC, and PC and increased mTORC1 signaling. Persistent hyper-activation of mTORC1 is associated with PC promotion. The activity of exosomal mRNA in cellular communication may lead to different impacts of different types of milk and whether or not mammalian milks will have their own characteristics within each species. Based on this review of the literature, it is possible to establish a relationship between the consumption of milk products and the progression of PC; we also found a possible association with PC initiation, hence it is likely that the intake of dairy products should be reduced or minimized in mens' diet.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fnut.2019.00062pt_PT
dc.identifier.eid85067798702
dc.identifier.issn2296-861X
dc.identifier.pmcPMC6527888
dc.identifier.pmid31139629
dc.identifier.urihttp://hdl.handle.net/10400.14/32432
dc.identifier.wos000468054700001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBCAAspt_PT
dc.subjectCancer preventionpt_PT
dc.subjectDairy productspt_PT
dc.subjectIGF-1pt_PT
dc.subjectMilkpt_PT
dc.subjectMTORCpt_PT
dc.subjectProstate cancerpt_PT
dc.subjectSignaling of mTORpt_PT
dc.titleDairy products: is there an impact on promotion of prostate cancer? A review of the literaturept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Nutritionpt_PT
oaire.citation.volume6pt_PT
person.familyNameRavasco
person.familyNameNeves
person.givenNamePaula
person.givenNamePedro
person.identifier381093
person.identifier459262
person.identifier.ciencia-id2E1E-155A-9B23
person.identifier.ciencia-id0219-A80A-F201
person.identifier.orcid0000-0002-6056-8269
person.identifier.orcid0000-0002-8641-8859
person.identifier.scopus-author-id6602551513
person.identifier.scopus-author-id57206372653
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2c8ebd2c-2f6d-4a0b-9271-dbe40af19875
relation.isAuthorOfPublication8860989d-7649-4eec-9a9e-6a85e1139f47
relation.isAuthorOfPublication.latestForDiscovery8860989d-7649-4eec-9a9e-6a85e1139f47

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