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Cardiovascular risk factors in Portuguese obese children and adolescents: impact of small reductions in body mass index imposed by lifestyle modifications

2012Journal article Open access
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dc.contributor.authorNascimento, Henrique
dc.contributor.authorCosta, Elísio
dc.contributor.authorRocha-Pereira, Petronila
dc.contributor.authorRego, Carla
dc.contributor.authorMansilha, Helena Ferreira
dc.contributor.authorQuintanilha, Alexandre
dc.contributor.authorSantos-Silva, Alice
dc.contributor.authorBelo, Luís
dc.date.accessioned2021-07-22T12:10:06Z
dc.date.available2021-07-22T12:10:06Z
dc.date.issued2012
dc.description.abstractObjectives: Evaluate cardiovascular risk factors in Portuguese obese children and adolescents and the long-term effects of lifestyle modifications on such risk factors. Design: Transversal cohort study and longitudinal study. Setting: University Hospital S. João and Children's Hospital Maria Pia, Porto. Patients/Participants: 148 obese children and adolescents [81 females (54.7%); mean age of 11.0 years]and 33 controls (sex and age matched) participated in a cross-sectional study. Sixty obese patients agreed to participate in an one year longitudinal study after medical and nutritionist appointments to improve lifestyle modification; a substantial body mass index (BMI) reduction was defined by a decrease in BMI z-score (BMI z-sc) of 0.3 or more over the studied period. Main Outcome measures: Lipid profile (triglycerides, cholesterol, HDLc, LDLc, lipoprotein (a), apolipoproteins A and B) and circulating levels of C-reactive protein (CRP), adiponectin, glucose, and insulin. Results: Compared with the lean children, obese patients demonstrated statistically significantly higher insulin resistance index [Homeostasis model assessment (HOMA)], and triglycerides, LDLc, apolipoprotein (apo) B, insulin and CRP concentrations, whereas their HDLc and apo A levels were significantly lower (cross-sectional study). In the longitudinal study (n=60), a substantial BMI reduction occurred in 17 (28.3%) obese patients which led to a significant reduction in triglycerides, cholesterol, LDLc, apo B, glucose and insulin levels and in HOMA. The ΔBMI values over the studied period correlated inversely and significantly with BMI (P<0.001) and HOMA (P=0.026) values observed at baseline. In multiple linear regression analysis, BMI at baseline remained associated to changes in BMI over the studied period (standardised Beta: -0.271, P=0.05). Conclusion: Our data demonstrates that small reductions in BMI-zc, imposed by lifestyle modifications in obese children and adolescents, improve the cardiovascular risk profile of such patients. Furthermore, patients with higher BMI and/or insulin resistance seem to experience a greater relative reduction in their BMI after lifestyle improvements.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/1874091X01206010043pt_PT
dc.identifier.eid84863791785
dc.identifier.issn1874-091X
dc.identifier.urihttp://hdl.handle.net/10400.14/34235
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectChildhood obesitypt_PT
dc.subjectInflammationpt_PT
dc.subjectInsulin resistancept_PT
dc.subjectLifestyle modificationspt_PT
dc.subjectLipid profilept_PT
dc.titleCardiovascular risk factors in Portuguese obese children and adolescents: impact of small reductions in body mass index imposed by lifestyle modificationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage50pt_PT
oaire.citation.startPage43pt_PT
oaire.citation.titleOpen Biochemistry Journalpt_PT
oaire.citation.volume6pt_PT
person.familyNameNascimento
person.familyNameCosta
person.familyNameRocha-Pereira
person.familyNameRego
person.familyNameQuintanilha
person.familyNameSantos-Silva
person.familyNameBelo
person.givenNameHenrique
person.givenNameElisio
person.givenNamePetronila
person.givenNameCarla
person.givenNameAlexandre
person.givenNameAlice
person.givenNameLuís
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person.identifier.orcid0000-0001-8544-0061
person.identifier.orcid0000-0002-2565-3169
person.identifier.orcid0000-0002-3941-6850
person.identifier.ridK-1990-2013
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person.identifier.ridL-5371-2013
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person.identifier.scopus-author-id25225780000
person.identifier.scopus-author-id7402527214
person.identifier.scopus-author-id55891444400
person.identifier.scopus-author-id7006496949
person.identifier.scopus-author-id7003831097
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person.identifier.scopus-author-id6602879850
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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