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Unraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cells

2021-09-01Journal article Open access
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dc.contributor.authorGomes, Ana T. P. C.
dc.contributor.authorNeves, M. Graça P. M. S.
dc.contributor.authorFernandes, Rosa
dc.contributor.authorRibeiro, Carlos F.
dc.contributor.authorCavaleiro, José A. S.
dc.contributor.authorMoura, Nuno M. M.
dc.date.accessioned2021-09-15T12:31:55Z
dc.date.available2021-09-15T12:31:55Z
dc.date.issued2021-09-01
dc.description.abstractIn this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/molecules26175312pt_PT
dc.identifier.eid85114375167
dc.identifier.issn1420-3049
dc.identifier.pmcPMC8434352
dc.identifier.pmid34500746
dc.identifier.urihttp://hdl.handle.net/10400.14/34878
dc.identifier.wos000694345200001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBenzoporphyrinpt_PT
dc.subjectCancerpt_PT
dc.subjectPhotodynamic therapypt_PT
dc.subjectPhotosensitizerpt_PT
dc.subjectPlatinum complexespt_PT
dc.titleUnraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue17pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume26pt_PT
person.familyNameGomes
person.familyNameNeves
person.familyNameFernandes
person.familyNameCavaleiro
person.familyNameMoura
person.givenNameAna Teresa Peixoto de Campos
person.givenNameMaria da Graça P. M. S.
person.givenNameRosa Cristina S
person.givenNameJose
person.givenNameNuno M. M.
person.identifierP-1102-2014
person.identifier.ciencia-id6612-501E-6A79
person.identifier.ciencia-idF51D-660B-07F3
person.identifier.ciencia-idF012-3425-8439
person.identifier.ciencia-id0C1B-0EB6-4767
person.identifier.orcid0000-0002-3201-0081
person.identifier.orcid0000-0002-7953-8166
person.identifier.orcid0000-0001-7828-2296
person.identifier.orcid0000-0001-5495-5126
person.identifier.orcid0000-0002-9373-7006
person.identifier.ridR-1895-2017
person.identifier.ridM-1560-2014
person.identifier.ridC-7379-2013
person.identifier.scopus-author-id55697408700
person.identifier.scopus-author-id35426389700
person.identifier.scopus-author-id35429612600
person.identifier.scopus-author-id14039621700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdc6dc93a-e504-4645-a70c-8f95f81589b5
relation.isAuthorOfPublication21f81486-b66b-444f-83b2-ce1fe0118340
relation.isAuthorOfPublication8a8bda16-70cf-459c-9dfb-c0be8ff364fe
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relation.isAuthorOfPublication.latestForDiscovery6d1e9777-c50b-46af-8491-9b31bb58d9b6

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