Browsing by Issue Date, starting with "2021-09-01"
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- O contributo das competências emocionais nos processos de mudança organizacional em contexto de teletrabalhoPublication . Ribeiro, Célia; Almeida, Tânia; Pereira, Paulo; Campos, Sofia; Figueira, Ana Paula Couceiro
- Is it possible to integrate palliative care in burn intensive care units? Results from a qualitative study with healthcare professionalsPublication . Ribeiro, A. F.; Hernández-Marrero, P.; Pereira, S. Martins
- Ethical challenges and decisions at the end-of-life in burn intensive care units. Results from a qualitative interview studyPublication . Pereira, S. Martins; Ribeiro, A. F.; Hernández-Marrero, P.
- End-of-life care in burn intensive care units: a systematically conducted scoping reviewPublication . Ribeiro, A. F.; Hernández-Marrero, P.; Pereira, S. Martins
- Unraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cellsPublication . Gomes, Ana T. P. C.; Neves, M. Graça P. M. S.; Fernandes, Rosa; Ribeiro, Carlos F.; Cavaleiro, José A. S.; Moura, Nuno M. M.In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells.
- Public procurement and innovationPublication . Caranta, Roberto; Gomes, Pedro CerqueiraInnovation has come to the forefront of EU public procurement. Directive 2014/24/EU has given contracting authorities in the Member States a new award procedure to pursue innovation, namely the innovation partnership. Still a number of issues remain open, notably concerning the allocation of intellectual property rights that may call for the application of State aids rules. Further guidance is thus expected from the Commission.