Logo do repositório
 
Publicação

Host-directed therapies based on protease inhibitors to control Mycobacterium tuberculosis and HIV coinfection

2025-04-30Artigo de revisão Acesso aberto
Ver registo simples
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMandal, Manoj
dc.contributor.authorPires, David
dc.contributor.authorAzevedo-Pereira, Jose Miguel
dc.contributor.authorAnes, Elsa
dc.date.accessioned2025-08-13T16:19:24Z
dc.date.available2025-08-13T16:19:24Z
dc.date.issued2025-04-30
dc.description.abstractDespite continuous and extensive global efforts in the fight against tuberculosis (TB), this infectious disease continues to exert a tremendous burden on public health concerns and deaths worldwide. TB, caused by the bacterial species Mycobacterium tuberculosis, is highly frequent in people living with HIV. The continuing epidemics of both chronic infections and the emergence of antimicrobial resistance, as well as the lack of effective diagnostic tools and drug–drug interactions, pose major challenges in the fight against these pathogens. Developing a wide range of host-directed therapies may improve treatment outcomes, helping alleviate the morbidity and mortality associated with both infections. In this review, we discuss the identification and development of new host-directed strategies based on protease inhibitors and their clinical relevance as adjunctive treatment. In the context of therapeutic agents with novel mechanisms, selective protease inhibitors, including saquinavir (SQV) and cystatins (CstC and CstF), are valuable targets that may provide effective therapeutic solutions for controlling Mtb and HIV coinfection.eng
dc.identifier.citationMandal, M., Pires, D., Azevedo-Pereira, J. M., & Anes, E. (2025). Host-directed therapies based on protease inhibitors to control Mycobacterium tuberculosis and HIV coinfection. Microorganisms, 13(5), Article 1040. https://doi.org/10.3390/microorganisms13051040
dc.identifier.doi10.3390/microorganisms13051040
dc.identifier.eid105006743334
dc.identifier.issn2076-2607
dc.identifier.otherf123653c-99af-4572-bad2-1a76c41e05c4
dc.identifier.pmcPMC12113826
dc.identifier.pmid40431213
dc.identifier.urihttp://hdl.handle.net/10400.14/54568
dc.identifier.wos001496341800001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCystatins
dc.subjectHIV coinfection
dc.subjectHost-directed therapies
dc.subjectProtease inhibitors
dc.subjectSaquinavir
dc.subjectTuberculosis
dc.titleHost-directed therapies based on protease inhibitors to control Mycobacterium tuberculosis and HIV coinfectioneng
dc.typereview article
dspace.entity.typePublication
oaire.citation.issue5
oaire.citation.titleMicroorganisms
oaire.citation.volume13
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
121231339.pdf
Tamanho:
3.29 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

CIIS - Contribuições em Revistas Científicas / Contribution to Journals