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Orientador(es)
Resumo(s)
The importance of stereochemistry for medicinal chemistry and pharmacology is well recognized and the dissimilar behavior of enantiomers is fully documented. Regarding the environment, the significance is equivalent since enantiomers of chiral organic pollutants can also differ in biodegradation processes and fate, as well as in ecotoxicity. This review comprises designed biodegradation studies of several chiral drugs and pesticides followed by enantioselective analytical methodologies to accurately measure the enantiomeric fraction (EF). The enantioselective monitoring of microcosms and laboratory-scale experiments with different environmental matrices is herein reported. Thus, this review focuses on the importance of evaluating the EF variation during biodegradation studies of chiral pharmaceuticals, drugs of abuse, and agrochemicals and has implications for the understanding of the environmental fate of chiral pollutants.
Descrição
Palavras-chave
Enantiomeric fraction (EF) Enantioselectivity Chiral analysis Biodegradation Pesticides Pharmaceuticals
Contexto Educativo
Citação
Maia, A. S., Ribeiro, A. R., Castro, P. M. L., & Tiritan, M. E. (2017). Chiral analysis of pesticides and drugs of environmental concern: Biodegradation and enantiomeric fraction. Symmetry-Basel, 9(9), 196
Editora
MDPI