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Can corrole dimers be good photosensitizers to kill bacteria?

2022-06-07Journal article Open access
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dc.contributor.authorLacerda, Paula S. S.
dc.contributor.authorBartolomeu, Maria
dc.contributor.authorGomes, Ana T. P. C.
dc.contributor.authorDuarte, Ana S.
dc.contributor.authorAlmeida, Adelaide
dc.contributor.authorFaustino, Maria A. F.
dc.contributor.authorNeves, Maria G. P. M. S.
dc.contributor.authorBarata, Joana F. B.
dc.date.accessioned2022-06-15T13:03:50Z
dc.date.available2022-06-15T13:03:50Z
dc.date.issued2022-06-07
dc.description.abstractCorroles possess key photophysical and photochemical properties to be exploited as thera-peutic agents in antimicrobial photodynamic therapy (aPDT). Herein, we present for the first time the antimicrobial efficiency of three corrole dimers and of the corresponding precursor against the Gram(+) bacterium Staphylococcus aureus. Additionally, to explore future clinical applications, the cytotoxicity of the most promising derivatives towards Vero cells was evaluated. The aPDT assays performed under white light irradiation (50 mW/cm2; light dose 450 J/cm2) and at a corrole concen-tration of 15 µM showed that some dimers were able to reduce 99.9999% of S. aureus strain (decrease of 5 log10 CFU/mL) and their photodynamic efficiency was dependent on position, type of linkage, and aggregation behavior. Under the same light conditions, the corrole precursor 1 demonstrated notable photodynamic efficiency, achieving total photoinactivation (>8.0 log10 CFU/mL reduction) after the same period of irradiation (light dose 450 J/cm2). No cytotoxicity was observed when Vero cells were exposed to corrole 1 and dimer 3 for 24 h according to ISO guidelines (ISO 10993-5) for in vitro cytotoxicity of medical devices. The results show that corrole dimers, dependent on their structures, can be considered good photosensitizers to kill Staphylococcus aureus.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/microorganisms10061167pt_PT
dc.identifier.eid85131334279
dc.identifier.issn2076-2607
dc.identifier.pmcPMC9230841
dc.identifier.pmid35744685
dc.identifier.urihttp://hdl.handle.net/10400.14/37881
dc.identifier.wos000818327600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobial photodynamic therapypt_PT
dc.subjectCorrole dimerspt_PT
dc.subjectCorrolespt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectPhotosensitizerspt_PT
dc.subjectStaphylococcus aureuspt_PT
dc.subjectUptakept_PT
dc.subjectVero cellspt_PT
dc.titleCan corrole dimers be good photosensitizers to kill bacteria?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.titleMicroorganismspt_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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