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Abstract(s)
O cancro surge como consequência de múltiplos eventos moleculares, resultando numa desregulação celular tendo como causa última a perda de homeostase celular. Alguns pacientes são susceptíveis a estes eventos de desregulação devido a características hereditárias, outros, por contacto com fatores exógenos que provocam a desregulação celular. Depois das doenças cardiovasculares o cancro é a patologia que mais mata em todo mundo a seguir, no entanto, se detetado em fases precoces torna-se menos debilitante e com uma superior taxa de sobrevivência.
Apesar do extenso volume de informação publicada e dedicada ao efeito de fatores com impacto na patologia carcinogénica, a terminologia utilizada não se encontra uniformizada nem organizada, dificultando a sua interpretação. Os sistemas de Informação que utilizam a tecnologia Web Semântica permitem a uniformização de terminologias dispersas.
O trabalho realizado no âmbito da presente dissertação visou a criação de um sistema de ontologias descritoras dos fatores associados a cancro que foram reunidos na ferramenta OntoXcancer. O OntoXcancer é uma ferramenta bioinformática que permite a gestão e análise de fatores associados a cancro e permitiu a construção da estrutura de uma base de dados - FactorXcancer. No âmbito desta dissertação, os fatores associados a cancro foram catalogados de acordo com as ontologias geradas pelo OntoXcancer e a informação bibliográfica referente a estes fatores permitiu o estabelecimento de uma estratégia metodológica para a consulta da informação disponível no FactorXcancer.
Cancer appears as a consequence of multiple molecular events resulting in cell disruption having as ultimate cause the loss of cellular homeostasis. Some patients are susceptible to these events of deregulation due to hereditary characteristics, others, by contact with external factors that caused cell disruption. Cancer has the second highest mortality rate all over the world, only behind cardiovascular diseases. However, if detected at an early stage, it becomes less debilitating and the survival rate increases. Despite the extensive amount of published data and dedicated investigations to best understand the factors that impact on carcinogenic pathology, the terminology is not standardized or organized, and this information remains difficult to interpret. Information Systems that use Semantic Web technology allow the standardization of dispersed terminologies, which will help in this matter. The work performed under this dissertation aimed to create a system of ontologies that could describe the factors associated with cancer. They were then gathered in OntoXcancer tool. The OntoXcancer is a bioinformatics tool that allows the management and analysis of factors associated with cancer and allowed the construction of a structured database - FactorXcancer. Within this dissertation, the cancer-associated factors were cataloged according to the ontologies generated by OntoXcancer and bibliographic information concerning these factors allowed the establishment of a methodology for consulting of the information available in FactorXcancer.
Cancer appears as a consequence of multiple molecular events resulting in cell disruption having as ultimate cause the loss of cellular homeostasis. Some patients are susceptible to these events of deregulation due to hereditary characteristics, others, by contact with external factors that caused cell disruption. Cancer has the second highest mortality rate all over the world, only behind cardiovascular diseases. However, if detected at an early stage, it becomes less debilitating and the survival rate increases. Despite the extensive amount of published data and dedicated investigations to best understand the factors that impact on carcinogenic pathology, the terminology is not standardized or organized, and this information remains difficult to interpret. Information Systems that use Semantic Web technology allow the standardization of dispersed terminologies, which will help in this matter. The work performed under this dissertation aimed to create a system of ontologies that could describe the factors associated with cancer. They were then gathered in OntoXcancer tool. The OntoXcancer is a bioinformatics tool that allows the management and analysis of factors associated with cancer and allowed the construction of a structured database - FactorXcancer. Within this dissertation, the cancer-associated factors were cataloged according to the ontologies generated by OntoXcancer and bibliographic information concerning these factors allowed the establishment of a methodology for consulting of the information available in FactorXcancer.
Description
Keywords
Ontologias Web semântica Cancro Ontologies SemanticWeb Cancer